Manufacturer of Aciphex
Eisai Inc.
Also know under brand names:
Aciphex: Patient Education
Patient education material for this drug is not currently available.
Active ingredient / generic name:
Aciphex: Patient Education
Patient education material for this drug is not currently available.
Approximate US Retail Price for Aciphex
Short leafletAciphex is an antiulcer drug in the class of proton pump inhibitors. It was developed by Eisai Co. and is marketed by Janssen-Cilag as Aciphex sodium under the brand names Aciphex and Pariet.
Aciphex is a prodrug (metabolized by the cytochrome P450 (or CYP450)) - in the acid environment of the parietal cells it turns into active sulphenamide form associated with cysteine of H+, K+ATPase (proton pump). Aciphex inhibits (partly reversibly) H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. Aciphex has anti Helicobacter pylori activity (MIC 4-16 mg/ml) and shows synergistic activity with some antibiotics. Aciphex has been demonstrated to be effective in patients with pathological hypersecretory activity (incl. Zollinger-Ellison Syndrome).
Aciphex Adverse reactions/Side effects include:
Aciphex decreases the concentration of ketoconazole in the plasma (in 33%), increases the concentration of digoxin (in 22%), and does not interact with liquid antiacids. Aciphex is compatible with any medicine metabolized by the CYP450 (theophylline, warfarin, diazepam, phenytoin).
There is no available data on symptoms of Aciphex overdose.
Aciphex as Aciphex,Rabeloc, Pariet is supplied in:
Aciphex: Patient Education
Aciphex: DosingGERD: 20 mg PO qd-bid x4-8wk: Info: may repeat x8wk if needed; maint. dose 20-40 mg/day; do not cut/crush/chew
esophagitis, erosive: 20 mg PO qd-bid x4-8wk: Info: may repeat x8wk if needed; maint. dose 20-40 mg/day; do not cut/crush/chew
duodenal ulcer: 20 mg PO qd x4wk: Info: may repeat x4wk if needed; do not cut/crush/chew
hypersecretory conditions: 60 mg PO qd: Max: 120 mg PO qd; Info: may divide dose bid; do not cut/crush/chew
H. pylori treatment: 20 mg PO bid x7 days: Info: use w/ amoxicillin and clarithromycin; do not cut/crush/chew
Aciphex: Drug Interactions
Aciphex vs atazanavir: avoid combo: combo may decr. atazanavir levels, efficacy and absorption decreased at higher gastric pH
Aciphex vs cefditoren: use alternative: combo may decr. cefditoren levels, efficacy and absorption decreased
Aciphex vs cefpodoxime: use alternative: combo may decr. cefpodoxime levels, efficacy and absorption decreased
Aciphex vs cefuroxime: use alternative: combo may decr. oral cefuroxime levels, efficacy and absorption decreased at higher gastric pH. Cefuroxime: also know as cefuroxime axetil, cefuroxime sodium
Aciphex vs dasatinib: use alternative: combo may decr. dasatinib levels, efficacy and absorption decreased at higher gastric pH
Aciphex vs delavirdine: use alternative: combo may decr. delavirdine efficacy and absorption decreased
Aciphex vs iron salts, oral: use alternative: combo may decr. iron efficacy and absorption decreased at higher gastric pH. Iron salts, oral: also know as ferrous gluconate, ferrous sulfate
Aciphex vs itraconazole: use alternative or admin. itraconazole w/ cola to incr. acidity: combo may decr. antifungal efficacy and absorption decreased, requires acid pH
Aciphex vs ketoconazole: use alternative or admin. ketoconazole w/ cola to incr. acidity: combo may decr. antifungal efficacy and absorption decreased, requires acid pH
Aciphex vs cyclosporine: monitor cyclosporine levels: combo may incr. cyclosporine levels, adverse effects and hepatic metab. inhibited. Cyclosporine: also know as cyclosporine modified, cyclosporine non-modified
Aciphex vs digoxin: monitor digoxin levels: combo may incr. digoxin levels, risk of toxicity and absorption increased
Aciphex vs sucralfate: give proton pump inhibitor 30min before sucralfate: combo may delay onset of proton pump inhibitor effect, decr. levels, efficacy and absorption delayed/decreased
Aciphex vs warfarin: monitor INR: combo may incr. INR, risk of bleeding and mechanism unknown
Aciphex vs digestive enzymes: caution advised, may be used for therapeutic advantage if severe pancreatic insufficiency: combo may result in premature dissolution, incr. or decr. efficacy of enteric-coated digestive enzyme products and gastric pH increased. Digestive enzymes: also know as pancreatin, pancrelipase
Aciphex vs fluconazole: caution advised: combo may incr. proton pump inhibitor levels, adverse effects and hepatic metab. inhibited
Aciphex vs fluvastatin: caution advised: combo may incr. fluvastatin levels, risk of myopathy, rhabdomyolysis and mechanism unknown, absorption possibly altered
Aciphex vs fluvoxamine: caution advised: combo may incr. proton pump inhibitor levels, adverse effects and hepatic metab. inhibited
Aciphex vs gefitinib: caution advised: combo may decr. gefitinib levels, efficacy and absorption decreased at higher gastric pH
Aciphex vs methylphenidate: caution advised w/ Ritalin LA only: combo may alter delayed-release properties of Ritalin LA; result in premature dissolution of enteric coated beads and gastric pH increased. Methylphenidate: also know as dexmethylphenidate, methylphenidate, methylphenidate transdermal
Aciphex vs penicillins: caution advised w/ oral penicillin, ampicillin, dicloxacillin: combo may decr. antimicrobial levels, efficacy and absorption decreased. Penicillins: also know as amoxicillin, amoxicillin/clavulanate, ampicillin, ampicillin/sulbactam, dicloxacillin, nafcillin, oxacillin, penicillin G benzathine, penicillin G potassium aqueous, penicillin G procaine, penicillin G sodium aqueous, penicillin VK, piperacillin, piperacillin/tazobactam, ticarcillin/clavulanate
Aciphex vs voriconazole: caution advised: combo may incr. proton pump inhibitor levels, adverse effects and hepatic metab. inhibited
Aciphex: Adverse Reactions
blood dyscrasias (rare)
hepatic dysfxn (rare)
anaphylactoid rxns (rare)
pancreatitis
Stevens-Johnson syndrome (rare)
toxic epidermal necrolysis (rare)
erythema multiforme (rare)
rhabdomyolysis (rare)
interstitial nephritis (rare)
hip fracture (long-term, >50 yo)
headache
diarrhea
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