Manufacturer of Atenolol
generic
Also know under brand names: Tenormin
Active ingredient / generic name: atenolol
Approximate US Retail Price for Atenolol 25 mg (90 ea): $11.99 50 mg (90 ea): $12.99 100 mg (90 ea): $15.89
Short leafletAtenolol is a β1 receptor specific antagonist, a drug belonging to the group of β-blockers, a class of drugs used primarily in cardiovascular diseases. Introduced in 1976, Atenolol was developed as a replacement for propranolol in the treatment of hypertension. The chemical works by slowing down the heart and reducing its workload. There is no evidence to suggest that it is addictive.
Unlike Propranolol, Atenolol does not pass through the blood-brain barrier thus avoiding various CNS side effects.
Whilst Atenolol, the most widely used β-blocker in the United Kingdom, was once first-line treatment for hypertension, the role for β-blockers in hypertension was downgraded in June 2006 in the United Kingdom to fourth-line as they perform less well than other drugs, particularly in the elderly, and there is increasing evidence that the most frequently used β-blockers at usual doses carry an unacceptable risk of provoking type 2 diabetes.
Atenolol (trade name Tenormin) can be used to treat cardiovascular diseases and conditions such as hypertension, coronary heart disease, arrhythmias, angina (chest pain) and to treat and reduce the risk of heart complications following myocardial infarction (heart attack)
Due to its hydrophilic properties, the drug is less suitable in migraine prophylaxis compared to propranolol, because for this indication, Atenolol would have to reach the brain in high concentrations, which is not the case (see below).
Atenolol is a so-called β1-selective (or 'cardioselective') drug. That means that it exerts greater blocking activity on myocardial β1-receptors than on β2 ones in the lung. The β2 receptors are responsible to keep the bronchial system open. If these receptors are blocked, bronchospasm with serious lack of oxygen in the body can result. However, due to its cardioselective properties, the risk of bronchospastic reactions if using Atenolol is reduced compared to nonselective drugs as propranolol. Nonetheless, this reaction may also be encountered with Atenolol, particularly with high doses. Extreme caution should be exerted if Atenolol is given to asthma patients, who are particularly at risk; the dose should be as low as possible. If an asthma attack occurs, the inhalation of a β2-mimetic antiasthmatic, such as hexoprenalin or salbutamol, will usually suppress the symptoms.
Provisional data suggests that antihypertensive therapy with Atenolol provides weaker protective action against cardiovascular complications (e.g. myocardial infarction and stroke) compared to other antihypertensive drugs. In particular, diuretics are superior. However, controlled studies are lacking.
Unlike most other commonly-used β-blockers, Atenolol is excreted almost exclusively by the kidneys. This makes it attractive for use in individuals with end-stage liver disease.
Caution: patients with preexisting asthma bronchiale
Caution: only if clearly needed during pregnancy, as Atenolol may retard fetal growth and possibly causes other abnormalities. (If you are pregnant or plan to become pregnant, ask your doctor.)
Atenolol causes significantly fewer central nervous system side effects (depressions, nightmares) and fewer bronchospastic reactions, both due to its particular pharmacologic profile.
It was the main β-blocker identified as carrying a higher risk of provoking type 2 diabetes, leading to its downgrading in the United Kingdom in June 2006 to fourth-line agent in the management of hypertension.
In addition, β-blockers blunt the usual sympathetic nervous system response to hypoglycemia (i.e. sweating, agitation, tachycardia). These drugs therefore have an ability to mask a dangerously low blood sugar, which further decreases their safety and utility in diabetic patients.
These side effects may or may not be experienced, but if they are, you should notify your doctor.
These side effects can be serious and may indicate urgent medical attention is necessary. All of these side effects are very rare, and others not mentioned in the above list can occur in some people.
In patients with normal renal function, the daily dose is 25 to 50 mg for the management of hypertension depending on the indication and severity of the disease. In most patients, the physician will start with a low initial dose and make increments in weekly intervals as tolerated. Dosage can vary from as little as 25 mg to 200mg a day. In cases of doses over 100mg, the dosage is usually divided and taken twice daily.
For the management of angina, 100mg daily may be given.
In patients with impaired renal function the daily dose should be reduced according to the clinical response of the individual patient. If a patient with end-stage renal failure is scheduled on regular dialysis, usually 50 mg are given after each dialysis procedure. In these patients, a severe hypotension may occur afterwards.
If Atenolol alone fails to control arterial hypertension, the drug can be combined with a diuretic (e.g. with chlortalidone in co-tenidone) and/or a vasodilator (hydralazine, or in severe cases minoxidil). Central alpha-agonists (e.g. clonidine), ACE Inhibitors or Angiotensin II receptor antagonists such as losartan can also be given additionally. Exert caution with calcium-antagonists of the verapamil-type as adjunct therapy because of additional negative impact on the muscular strength of the heart. Use of calcium-antagonists of the nifedipine-type is controversial.
Symptoms of overdose are due to excessive pharmacodynamic actions on β1 and also β2-receptors. These include bradycardia, severe hypotension with shock, acute heart failure, hypoglycemia and bronchospastic reactions. Treatment is largely symptomatic. Hospitalization and intensive monitoring is indicated. In early cases emesis can be induced. Activated charcoal is useful to absorb the drug. Atropine will counteract bradycardia, glucagon helps with hypoglycemia, dobutamine can be given against hypotension and the inhalation of a β2-mimetic as hexoprenalin or salbutamol will terminate bronchospasms.
atenolol: Patient Education
Do not stop taking atenolol without first talking to your doctor. Stopping suddenly
may make your condition worse.
If you need to have any type of surgery, you may need to temporarily stop using atenolol.
Be sure the surgeon knows ahead of time that you are using atenolol.
Atenolol can cause side effects that may impair your thinking or reactions. Be
careful if you drive or do anything that requires you to be awake and alert.
Avoid drinking alcohol, which could increase drowsiness and dizziness while you are
taking atenolol.
Atenolol is only part of a complete program of treatment for hypertension that may also
include diet, exercise, and weight control. Follow your diet, medication, and exercise routines
very closely if you are being treated for hypertension.
Hypertension often has no symptoms, so you may not even feel that you have high blood
pressure. Continue using this medicine as directed, even if you feel well. You may need to use
blood pressure medication for the rest of your life.
Atenolol is in a group of drugs called beta-blockers. Beta-blockers affect the heart and
circulation (blood flow through arteries and veins).
Atenolol is used to treat angina (chest pain) and hypertension (high blood pressure). It is
also used to treat or prevent heart attack.
Atenolol may also be used for purposes other than those listed in this medication guide.
Before taking atenolol, tell your doctor if you have:
asthma, bronchitis, emphysema;
diabetes;
low blood pressure;
a heart problem such as heart block, sick sinus syndrome,
slow heart rate, or congestive heart failure;
depression;
liver or kidney disease;
a thyroid disorder;
myasthenia gravis;
pheochromocytoma; or
problems with circulation (such as Raynaud's syndrome).
If you have any of these conditions, you may not be able to use
atenolol, or you may need a dosage adjustment or special tests during treatment.
FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use atenolol if you are pregnant. Tell your doctor if you become
pregnant during treatment. Use an effective form of birth control while you are using this
medication.
Atenolol can pass into breast milk and may harm a nursing baby. Do not use this
medication without telling your doctor if you are breast-feeding a baby.
Take atenolol exactly as it was prescribed for you. Do not take the medication in larger
amounts or for longer than recommended by your doctor.
Take this medication with a full glass of water.
Take atenolol at the same time every day.
Do not skip doses or stop taking atenolol without first talking to your doctor.
Stopping suddenly may make your condition worse.
To be sure this medication is helping your condition, your blood pressure will need to be
checked on a regular basis. It is important that you not miss any scheduled visits to your doctor.
If you need to have any type of surgery, tell the surgeon that you are using atenolol. You
may need to briefly stop using atenolol before having surgery.
Atenolol is only part of a complete program of treatment for hypertension that may also
include diet, exercise, and weight control. Follow your diet, medication, and exercise routines
very closely if you are being treated for hypertension.
Hypertension often has no symptoms, so you may not even feel that you have high blood
pressure. Continue using this medicine as directed, even if you feel well. You may need to use
blood pressure medication for the rest of your life.
Store atenolol at room temperature away from moisture and heat.
Take the missed dose as soon as you remember. If your next dose is less than 8 hours
away, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention if you think you have used too much of this
medicine.
Symptoms of an atenolol overdose may include uneven heartbeats, shortness of breath,
bluish-colored fingernails, dizziness, weakness, fainting, or seizure (convulsions).
Atenolol can cause side effects that may impair your thinking or reactions. Be
careful if you drive or do anything that requires you to be awake and alert.
Avoid drinking alcohol, which could increase drowsiness and dizziness while you are
taking atenolol.
Get emergency medical help if you have any of these signs of an allergic
reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
slow or uneven heartbeats;
feeling light-headed, fainting;
feeling short of breath, even with mild exertion;
swelling of your ankles or feet;
nausea, stomach pain, low fever, loss of appetite, dark
urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
depression; or
cold feeling in your hands and feet.
Other less serious side effects are more likely to occur, such as:
decreased sex drive, impotence, or difficulty having an orgasm;
sleep problems (insomnia);
tired feeling; or
anxiety, nervousness.
Side effects other than those listed here may also occur. Talk to your
doctor about any side effect that seems unusual or that is especially bothersome.
Before taking atenolol, tell your doctor if you are using:
allergy treatments (or if you are undergoing allergy skin-testing);
clonidine (Catapres);
guanabenz (Wytensin);
an MAO inhibitor such as isocarboxazid (Marplan),
tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam);
a diabetes medication such as insulin, glyburide (Diabeta,
Micronase, Glynase), glipizide (Glucotrol), chlorpropamide (Diabinese), or metformin
(Glucophage);
a heart medication such as nifedipine (Procardia, Adalat),
reserpine (Serpasil), verapamil (Calan, Verelan, Isoptin), diltiazem (Cartia, Cardizem);
medicine for asthma or other breathing disorders, such as
albuterol (Ventolin, Proventil), bitolterol (Tornalate), metaproterenol (Alupent), pirbuterol
(Maxair), terbutaline (Brethaire, Brethine, Bricanyl), and theophylline (Theo-Dur, Theolair); or
cold medicines, stimulant medicines, or diet pills.
If you are using any of these drugs, you may not be able to take
atenolol, or you may need dosage adjustments or special tests during treatment.
There may be other drugs not listed that can affect atenolol. Tell your doctor about all the
prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal
products, and drugs prescribed by other doctors. Do not start using a new medication without
telling your doctor.
Your pharmacist has additional information about atenolol written for health
professionals that you may read.
Atenolol: DosingHTN: 50-100 mg PO qd: Start: 50 mg PO qd, may incr. dose after 7-14 days; Max: 100 mg/day
angina: 50-200 mg PO qd: Start: 50 mg PO qd, may incr. dose after 7 days; Max: 200 mg/day; Info: taper dose gradually to D/C
cardiovascular event prevention, post-MI: 100 mg/day PO div qd-bid: Info: start ASAP after pt stable
renal dosing: adjust dose amount, frequency: CrCl 10-50: decr. dose 50%, give q48h, max 50 mg/day; CrCl <10: decr. dose 50-70%, give q96h, max 25 mg/day; HD: give 25-50 mg supplement; CAPD: no supplement
atenolol: Drug Interactions
atenolol vs central alpha 2 agonists: use alternative or monitor BP, D/C beta blocker first: combo may decr. antihypertensive response to alpha 2 agonist, incr. risk of severe rebound HTN on alpha 2 agonist withdrawal and antagonistic effects, unopposed alpha adrenergic stimulation. Central alpha 2 agonists: also know as clonidine, clonidine transdermal, guanabenz, guanfacine, methyldopa
atenolol vs cimetidine: use alternative or non-hepatically metabolized beta blocker e.g. atenolol, nadolol: combo may incr. risk of bradycardia, hypotension and hepatic metab. inhibited
atenolol vs cocaine topical: avoid combo: combo may result in unopposed alpha-adrenergic stimulation w/ incr. risk of HTN, severe vasoconstriction, arrhythmias and additive effects
atenolol vs COX 2 inhibitors: monitor BP, use alternative: combo may cause sodium/water retention, decr. antihypertensive efficacy and antagonistic effects. COX 2 inhibitors: also know as celecoxib
atenolol vs fenoldopam: avoid combo: combo may incr. risk of hypotension and beta blocker interference w/ reflex tachycardia; additive effects
atenolol vs hydrocodone/ibuprofen: monitor BP, consider alternatives: combo may decr. antihypertensive efficacy and antagonistic effect due to NSAID-induced inhibition of renal prostaglandins, sodium and fluid retention
atenolol vs ibuprofen/oxycodone: monitor BP, consider alternatives: combo may decr. antihypertensive efficacy and antagonistic effect due to NSAID-induced inhibition of renal prostaglandins, sodium and fluid retention
atenolol vs insulins: use alternative: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism. Insulins: also know as insulin aspart, insulin aspart protamine/insulin aspart, insulin detemir, insulin glargine, insulin glulisine, insulin inhaled, insulin lispro, insulin lispro protamine/insulin lispro, insulin NPH, insulin NPH/regular, insulin regular
atenolol vs lansoprazole/naproxen: monitor BP, consider alternatives: combo w/ NSAIDs may cause sodium/water retention, decr. antihypertensive efficacy and antagonistic effects
atenolol vs NSAIDs: monitor BP, consider alternatives: combo may decr. antihypertensive efficacy and antagonistic effect due to NSAID-induced inhibition of renal prostaglandins, sodium and fluid retention. NSAIDs: also know as diclofenac potassium, diclofenac sodium, diclofenac/misoprostol, diflunisal, etodolac, fenoprofen, flurbiprofen, ibuprofen, ibuprofen lysine, indomethacin, ketoprofen, ketorolac, meclofenamate, mefenamic acid, meloxicam, nabumetone, naproxen, naproxen sodium, oxaprozin, piroxicam, sulindac, tolmetin
atenolol vs alfuzosin: caution advised, monitor BP, HR: combo may incr. levels of both drugs, risk of hypotension, bradycardia and mechanism unknown
atenolol vs alpha 2 agonists, ophthalmic: caution advised, monitor BP, HR: combo may incr. risk of hypotension, bradycardia, AV block and additive effects. Alpha 2 agonists, ophthalmic: also know as apraclonidine ophthalmic, brimonidine ophthalmic
atenolol vs alpha 2 agonists/beta blockers, ophthalmic: caution advised, monitor BP, HR, IOP: combo may incr. risk of hypotension, bradycardia, AV block, decr. IOP and additive effects. Alpha 2 agonists/beta blockers, ophthalmic: also know as brimonidine/timolol ophthalmic
atenolol vs amiodarone: monitor HR: combo may incr. risk of bradycardia, sinus arrest, AV block and additive effects
atenolol vs antihist/decongestant combos: caution advised, monitor BP: combo w/ decongestants may decr. antihypertensive efficacy and antagonistic effects. Antihist/decongestant combos: also know as acrivastine/pseudoephedrine, brompheniramine/phenylephrine, chlorpheniramine/phenylephrine, chlorpheniramine/pseudoephedrine, pseudoephedrine/triprolidine
atenolol vs aspirin/butalbital/caffeine: caution advised, monitor BP: combo w/ high dose aspirin or salicylates may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention
atenolol vs aspirin/butalbital/caffeine/codeine: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention
atenolol vs aspirin/caffeine/dihydrocodeine: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive efficacy and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention
atenolol vs aspirin/caffeine/orphenadrine: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention
atenolol vs aspirin/dipyridamole: caution advised, monitor BP: combo w/ high dose aspirin or salicylates may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention
atenolol vs aspirin/muscle relaxant combos: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention. Aspirin/muscle relaxant combos: also know as aspirin/carisoprodol
atenolol vs aspirin/opiate combos: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention. Aspirin/opiate combos: also know as aspirin/carisoprodol/codeine, aspirin/codeine, aspirin/oxycodone
atenolol vs atazanavir: monitor BP, ECG, consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. risk of hypotension, bradycardia, AV block, prolonged PR interval and hepatic metab. inhibited, additive effects
atenolol vs beta blockers, ophthalmic: caution advised, monitor BP, HR, IOP: combo may incr. risk of hypotension, bradycardia, AV block, decr. IOP and additive effects. Beta blockers, ophthalmic: also know as betaxolol ophthalmic, carteolol ophthalmic, dorzolamide/timolol ophthalmic, levobunolol ophthalmic, metipranolol ophthalmic, timolol ophthalmic
atenolol vs bismuth subsalicylate/metronidazole/tetracycline: caution advised w/ high-dose aspirin or salicylates; monitor BP: combo may decr. antihypertensive efficacy and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention
atenolol vs CCBs, others: weigh risk/benefit; monitor cardiac fxn closely: combo may incr. risk of hypotension, bradycardia, AV block, conduction defects and additive effects, hepatic metab. of some beta blockers inhibited. CCBs, others: also know as diltiazem, trandolapril/verapamil, verapamil
atenolol vs dexmedetomidine: monitor BP, ECG: combo may incr. risk of bradycardia, hypotension and additive effects
atenolol vs diazoxide: monitor BP, glucose: combo may incr. or decr. diazoxide hyperglycemic effects; combo w/ IV diazoxide may incr. risk of hypotension and additive/antagonistic effects; additive effects
atenolol vs digoxin: monitor ECG: combo may incr. risk of bradycardia, AV block and additive effects
atenolol vs hypoglycemics, other: monitor glucose: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism. Hypoglycemics, other: also know as acarbose, metformin, miglitol, nateglinide, repaglinide, sitagliptin/metformin
atenolol vs inhaled anesthetics: caution advised, monitor BP; use for therapeutic advantage to decr BP during surgery: combo may cause prolonged hypotension, decr. cardiac output, other myocardial depressant effects and additive/synergistic effects. Inhaled anesthetics: also know as desflurane, enflurane, isoflurane, sevoflurane
atenolol vs lanreotide: monitor BP, HR; consider lower beta blocker dose: combo may result in bradycardia, altered BP and cardiac conduction abnormalities and additive effects, antagonistic effects
atenolol vs mefloquine: caution advised, monitor ECG: combo may incr. risk of ECG abnormalities, cardiac arrest and mechanism unknown
atenolol vs metformin/sulfonylurea combos: monitor glucose: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism. Metformin/sulfonylurea combos: also know as glipizide/metformin, glyburide/metformin
atenolol vs octreotide: monitor BP, HR; consider lower beta blocker dose: combo may result in bradycardia, altered BP and cardiac conduction abnormalities and additive effects, antagonistic effects
atenolol vs pramlintide: monitor glucose: combo may cause hyperglycemia, prolonged hypoglycemia, mask hypoglycemic sx and adrenergic antagonism
atenolol vs propafenone: caution advised, consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of AV block, other adverse effects and hepatic metab. inhibited; additive effects
atenolol vs quinidine: caution advised, consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. risk of bradycardia, AV block and hepatic metab. inhibited; additive effects. Quinidine: also know as quinidine gluconate, quinidine sulfate
atenolol vs salicylates, non-acetylated: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention. Salicylates, non-acetylated: also know as bismuth subsalicylate, choline magnesium trisalicylate, salsalate
atenolol vs thiazolidinediones: monitor glucose: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism. Thiazolidinediones: also know as metformin/pioglitazone, metformin/rosiglitazone, pioglitazone, pioglitazone/glimepiride, rosiglitazone, rosiglitazone/glimepiride
atenolol vs tizanidine: caution advised, monitor BP: combo may incr. risk of hypotension and additive effects
atenolol vs alfentanil: caution advised: combo may incr. risk of bradycardia, hypotension and additive effects
atenolol vs alpha blockers, non-selective: caution advised: combo may incr. first-dose hypotension, postural hypotension and additive effects. Alpha blockers, non-selective: also know as doxazosin, prazosin, terazosin
atenolol vs amitriptyline/perphenazine: caution advised: combo may incr. risk of hypotension and additive effects
atenolol vs antihist/decongest/DM combos: caution advised: combo w/ decongestants may decr. antihypertensive efficacy and antagonistic effects. Antihist/decongest/DM combos: also know as brompheniramine/dextromethorphan/pseudoephedrine, chlorpheniramine/phenylephrine/dextromethorphan
atenolol vs apomorphine: caution advised: combo may incr. risk of orthostatic hypotension, MI, pneumonia, falls, other apomorphine adverse effects and additive effects
atenolol vs beta 2 agonists, all: caution advised: combo may decr. bronchodilating effects, cause bronchospasm; beta 1 cardioselective agents less likely to interact and antagonistic effects. Beta 2 agonists, all: also know as albuterol, albuterol inhaled, albuterol/ipratropium inhaled, arformoterol inhaled, budesonide/formoterol inhaled, fluticasone/salmeterol inhaled, formoterol inhaled, isoproterenol, levalbuterol inhaled, metaproterenol, pirbuterol inhaled, salmeterol inhaled, terbutaline
atenolol vs cetirizine/pseudoephedrine: caution advised: combo may decr. antihypertensive efficacy and antagonistic effects
atenolol vs cholinergic agents: caution advised: combo may alter cardiac conduction and additive effects. Cholinergic agents: also know as bethanechol, cevimeline, pilocarpine
atenolol vs cholinesterase inhibitors: caution advised: combo may alter cardiac conduction, incr. risk of bradycardia, AV block; may incr. risk of bronchospasm and additive effects. Cholinesterase inhibitors: also know as donepezil, edrophonium, galantamine, neostigmine, physostigmine, pyridostigmine, rivastigmine, tacrine
atenolol vs cyclopentolate/phenylephrine ophthalmic: caution advised: combo may rarely cause severe HTN; beta-1 selective agents less likely to interact and antagonistic effects
atenolol vs decongest/opiate combos: caution advised: combo may decr. antihypertensive efficacy and antagonistic effects. Decongest/opiate combos: also know as guaifenesin/hydrocodone/phenylephrine
atenolol vs decongestants: caution advised: combo may decr. antihypertensive efficacy and antagonistic effects. Decongestants: also know as desloratadine/pseudoephedrine, fexofenadine/pseudoephedrine, guaifenesin/phenylephrine, guaifenesin/pseudoephedrine, loratadine/pseudoephedrine, pseudoephedrine
atenolol vs decongestants, intranasal: caution advised: combo may rarely cause severe HTN; beta-1 selective agents less likely to interact and antagonistic effects. Decongestants, intranasal: also know as oxymetazoline nasal, phenylephrine nasal
atenolol vs diclofenac topical: monitor BP, consider alternatives: combo may decr. antihypertensive efficacy and antagonistic effect; up to 10% systemic absorption of diclofenac topical gel; minimal absorption w/ patch. Diclofenac topical: also know as diclofenac epolamine topical, diclofenac topical
atenolol vs disopyramide: caution advised: combo may incr. risk of cardiac conduction disturbances and additive effects
atenolol vs epinephrine, inhaled: caution advised: combo w/ beta blockers may cause severe HTN then bradycardia, may decr. cardiostim/bronchodilat. effects; beta 1 selective agents less likely to interact and antagonistic effects. Epinephrine, inhaled: also know as epinephrine inhaled, epinephrine, racemic inhaled
atenolol vs ergot alkaloids: caution advised: combo may incr. risk of peripheral vasoconstriction, ischemia and synergistic effects. Ergot alkaloids: also know as dihydroergotamine, dihydroergotamine nasal, methylergonovine
atenolol vs ergotamine/caffeine: caution advised: combo may incr. risk of peripheral vasoconstriction, ischemia and synergistic effects
atenolol vs fibric acid derivatives: caution advised: combo may decr. fibric acid derivative efficacy; beta blockers may exacerbate hypertriglyceridemia and antagonistic effects. Fibric acid derivatives: also know as fenofibrate, fenofibrate micronized, gemfibrozil
atenolol vs flecainide: caution advised: combo may incr. risk of bradycardia, AV block and additive effects
atenolol vs iloprost inhaled: caution advised: combo may incr. risk of hypotension and additive/synergistic effects
atenolol vs local anesthetics/epinephrine: caution advised: combo w/ epinephrine may cause severe HTN then bradycardia, may decr. cardiostim/bronchodilatory effects; beta 1 selective agents less likely to interact and antagonistic effects. Local anesthetics/epinephrine: also know as articaine/epinephrine
atenolol vs MAOIs, non-selective: caution advised: combo may incr. risk of hypotension and additive effects. MAOIs, non-selective: also know as isocarboxazid, phenelzine, procarbazine, selegiline transdermal, tranylcypromine
atenolol vs maraviroc: caution advised: combo may incr. risk of orthostatic hypotension and additive effects
atenolol vs meperidine/promethazine: caution advised: combo may incr. risk of hypotension and additive effects
atenolol vs morphine liposomal: caution advised: combo may incr. risk of orthostatic hypotension and additive effects
atenolol vs nitrites/sodium thiosulfate: caution advised: combo w/ nitrites may incr. risk of hypotension and additive effects. Nitrites/sodium thiosulfate: also know as amyl nitrite/sodium nitrite/sodium thiosulfate
atenolol vs omega-3-acid: caution advised: combo may antagonize antihyperlipidemic effect of omega-3-acid and antagonistic effects. Omega-3-acid: also know as omega-3-acid ethyl esters
atenolol vs phenothiazines: caution advised: combo may incr. risk of hypotension and additive effects. Phenothiazines: also know as chlorpromazine, fluphenazine, fluphenazine decanoate, perphenazine, prochlorperazine edisylate, prochlorperazine maleate, prochlorperazine rectal, promethazine, promethazine rectal, thioridazine, trifluoperazine
atenolol vs phenylephrine ophthalmic: caution advised: combo may rarely cause severe HTN; beta-1 selective agents less likely to interact and antagonistic effects
atenolol vs promethazine/codeine: caution advised: combo may incr. risk of hypotension and additive effects
atenolol vs reserpine: caution advised: combo may incr. risk of orthostatic hypotension, bradycardia, depression and beta blocker interference w/ reflex tachycardia; additive effects
atenolol vs sitagliptin: caution advised: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism
atenolol vs sotalol: caution advised: combo may incr. risk of hypotension, bradycardia, AV block and additive effects. Sotalol: also know as sotalol, sotalol AF
atenolol vs sufentanil: caution advised: combo w/ beta blockers may incr. risk of bradycardia, hypotension and additive effects
atenolol vs sulfonylureas: caution advised: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism. Sulfonylureas: also know as chlorpropamide, glimepiride, glipizide, glyburide, glyburide micronized, tolazamide, tolbutamide
atenolol vs sympathomimetics, direct: caution advised: combo may cause severe HTN then bradycardia, may decr. cardiostim/bronchodilat. effects; beta 1 selective agents less likely to interact and antagonistic effects. Sympathomimetics, direct: also know as dobutamine, epinephrine, isoproterenol, norepinephrine, phenylephrine
atenolol vs sympathomimetics, indirect/mixed: caution advised: combo may decr. vasopressor, cardiostimulating, bronchodilating effects; beta 1 selective agents less likely to interact and antagonistic effects. Sympathomimetics, indirect/mixed: also know as acetaminophen/dichloralphenazone/isometheptene, dopamine, ephedrine
atenolol vs tadalafil: caution advised: combo may incr. risk of hypotension and additive effects
atenolol: Adverse Reactions
CHF
heart block
bradycardia, severe
arrhythmias
Raynaud's phenomenon
bronchospasm
hypersensitivity rxn
bradycardia
hypotension
fatigue
dizziness
cold extremities
depression
dyspnea
postural hypotension
leg pain
bronchospasm
lightheadedness
lethargy
diarrhea
nausea
vertigo
drowsiness
|