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Manufacturer of Avelox

Schering-Plough Corp.

Also know under brand names: Avelox, Avelox I.V.

Active ingredient / generic name: moxifloxacin

Approximate US Retail Price for Avelox

400 mg (30 ea): $343.30

Short leaflet

Avelox is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. Each tablet contains 400 mg. In most countries the drug is also available in parenteral form for intravenous infusion. Avelox is also sold in an ophthalmic solution (eye drops) under the name Vigamox for the treatment of conjunctivitis.

Avelox inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV. Topoisomerases are essential enzymes which play a crucial role in the replication and repair of bacterial DNA. This mechanism is lethal to susceptible bacteria. Avelox is often referred to as a chemotherapeutic drug because its mode of action has so far not been noted in any naturally occurring or semi-synthetic antibiotic.

With either oral or intravenous administration, Avelox is found in high concentrations in body tissues and fluids, such as saliva, nasal and bronchial secretions, sinus mucosa, skin blister fluid, and subcutaneous and intraocular tissues. There is good penetration into bone. Pus does not seem to easily inhibit the drug's potential to reach effective concentrations in infectious foci. Avelox does not reach appreciable levels in the kidney or urinary tract.

A broad spectrum of bacteria is susceptible including, but not limited to:

Mild, moderate and severe renal dysfunction does not alter half-life, metabolization or excretion significantly. The same is true to for mild to moderate liver impairment (Child-Pugh class A and B). Nothing is known about severe liver impairment (Child-Pugh class C).

Avelox can be used to treat respiratory infections, including acute sinusitis, acute exacerbations of chronic bronchitis, and community-acquired pneumonia, as well as skin and skin structure infections. Avelox is also used for the treatment of complicated intra-abdominal infections, such as those seen in hospitals. Because Avelox is primarily metabolized and eliminated via the hepatic route, it is not indicated for the treatment of urinary tract infections.

Avelox is used as a second-line agent in tuberculosis (TB) and may potentially have benefits in reducing treatment duration from its current six month to four months.

In ophthalmology, Avelox is available the form of eye drops, marketed by Alcon as Vigamox, to treat conjunctival infections caused by susceptible bacteria and to prevent infection following eye surgeries such as LASIK.

Resistance to Avelox arises in Mycobacterium tuberculosis if Avelox is used alone instead of in combination with other anti-TB drugs, and this appears to be the explanation for the appearance of Avelox resistance in newly diagnosed TB patients in Baltimore and in Taiwan. Of concern is that the development of resistance can appear in as short a time as seven days. This calls into question the first line use of Avelox and other respiratory quinolones as first line therapy for the treatment of community-acquired pneumonia in populations where TB is still endemic.

Avelox can be given orally as 400-mg film-coated tablets or intravenously as 250-mL flexibags containing a sterile, preservative-free, 0.8% sodium chloride aqueous solution of Avelox hydrochloride (containing 400 mg Avelox). The usual dosage is 400 mg daily orally or via intravenous infusion over 1 hour. The duration of treatment depends on the disease and ranges from 5 days in acute exacerbations of chronic bronchitis to 60 days for post-exposure prophylaxis of anthrax. The bioavailability of Avelox is greater than 90% and therefore there are no advantages to using intravenous Avelox when the patient is able to swallow tablets. Bioavailability is markedly reduced, however, when Avelox is taken with sucralfate or aluminum-containing antacids. The intravenous preparation is not licensed for use in the UK.

Except for the ophthalmic form, there are insufficient clinical data on dosage to patients under 18 years of age. In geriatric patients, no dose reductions are necessary.

Possible side effects include gastrointestinal tract disturbances (nausea, vomiting, anorexia, bloating, abdominal pain, diarrhea, and pseudomembranous colitis caused by Clostridium difficile), skin reactions (also Stevens-Johnson syndrome), rhabdomyolysis, and serious heart problems (prolonged QT interval and torsades de pointes). Development of resistance has been noticed as well as rare cases of hepatotoxicity and seizures. Tendon rupture (including rupture of the Achilles tendon) can also occur.

Avelox may have a much higher attack rate of Clostridium difficile than other respiratory quinolones, such as levofloxacin.

Antacids containing aluminium or magnesium ions inhibit the absorption of Avelox. Drugs that prolong the QT interval (e.g. pimozide) may have an additive effect on QT prolongation and lead to increased risk of ventricular arrhythmias. The INR (International Normalised Ratio) may be increased or decreased in patients treated with warfarin. A precautionary measure would be to monitor the INR more closely and, if necessary, adjust the anticoagulant dose as necessary.

Unlike ciprofloxacin, Avelox has no interactions with warfarin or theophylline.

Avelox: Patient Education

Take this medication for as many days as it has been prescribed for you even if you begin to feel better. Your symptoms may start to improve before the infection is completely treated. Moxifloxacin will not treat a viral infection such as the common cold or flu.

Do not use moxifloxacin without first talking to your doctor if you or any member of your family have a heart condition known as long QT syndrome. Also, do not use moxifloxacin if you are also using a heart rhythm medicine such as quinidine (Cardioquin, Quinidex, Quinaglute), procainamide (Pronestyl, Procan SR), amiodarone (Cordarone, Pacerone), sotalol (Betapace), and others.

Certain other drugs can make moxifloxacin less effective when taken at the same time. The following medicines should be taken at least 4 hours after or 8 hours before you take moxifloxacin: antacids that contain magnesium, calcium, or aluminum (such as Tums, Rolaids, Maalox); the ulcer medicine sucralfate (Carafate); vitamin or mineral supplements that contain iron or zinc; didanosine chewable/buffered tablets or pediatric powder for oral solution (ddI, Videx, Videx Pediatric, and others).

Moxifloxacin may make your skin more sensitive to sunburn. Avoid prolonged exposure to sunlight or tanning beds, and wear protective clothing and sunscreen when you are outdoors. Call your doctor if you have severe burning, redness, itching, rash, or swelling after being in the sun.

Moxifloxacin is an antibiotic in the class of drugs called fluoroquinolones. It fights bacteria in the body.

Moxifloxacin is used to treat bacterial infections.

Moxifloxacin may also be used for purposes other than those listed in this medication guide.

Do not use moxifloxacin without first talking to your doctor if you or any member of your family have a heart condition known as long QT syndrome. Also, do not use moxifloxacin if you are also using a heart rhythm medicine such as quinidine (Cardioquin, Quinidex, Quinaglute), procainamide (Pronestyl, Procan SR), amiodarone (Cordarone, Pacerone), sotalol (Betapace), and others.

Before taking moxifloxacin, tell your doctor if you:

Moxifloxacin is in the FDA pregnancy category C. This means that it is not known whether moxifloxacin will be harmful to an unborn baby. Do not use moxifloxacin without telling your doctor if you are pregnant or could become pregnant during treatment.

Moxifloxacin may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Moxifloxacin should not be used by children younger than 18 years of age.

Moxifloxacin should be used exactly as your doctor has prescribed it for you. Do not use more of the medication than recommended. Do not take moxifloxacin for longer than your doctor has prescribed.

Take each oral dose with a full glass (8 ounces) of water. Drink plenty of fluid while taking moxifloxacin.

Take this medication for as many days as it has been prescribed for you even if you begin to feel better. Your symptoms may start to improve before the infection is completely treated. Moxifloxacin will not treat a viral infection such as the common cold or flu.

Moxifloxacin is sometimes given as an intravenous (IV) infusion through a needle placed in one of your veins. Moxifloxacin IV is given slowly over a period of one hour.

Store this medication at room temperature away from moisture and heat.

Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take extra medicine to make up the missed dose.

It is best to take each dose of moxifloxacin at the same time each day.

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a moxifloxacin overdose may include extreme sleepiness, seizures, tremors, vomiting or diarrhea.

Avoid prolonged exposure to sunlight or tanning beds. Moxifloxacin may make your skin more sensitive to sunburn. Wear protective clothing and use sunscreen if you must be out in the sun while using moxifloxacin. Call your doctor if you have severe burning, redness, itching, rash, or swelling after being in the sun.

Moxifloxacin can cause side effects that may impair your thinking or reactions. If this happens, avoid driving or doing anything that requires you to be awake and alert.

Stop using moxifloxacin and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

If you have diarrhea while using moxifloxacin, call your doctor before using any medicine to stop the diarrhea, especially if it is watery or contains blood.

Do not use moxifloxacin without first talking to your doctor if you or any member of your family have a heart condition known as long QT syndrome. Also, do not use moxifloxacin if you are also using a heart rhythm medicine such as quinidine (Cardioquin, Quinidex, Quinaglute), procainamide (Pronestyl, Procan SR), amiodarone (Cordarone, Pacerone), sotalol (Betapace), and others.

Certain other drugs can make moxifloxacin less effective when taken at the same time. The following medicines should be taken at least 4 hours after or 8 hours before you take moxifloxacin: antacids that contain magnesium, calcium, or aluminum (such as Tums, Rolaids, Maalox); the ulcer medicine sucralfate (Carafate); vitamin or mineral supplements that contain iron or zinc; didanosine chewable/buffered tablets or pediatric powder for oral solution (ddI, Videx, Videx Pediatric, and others).

Before using moxifloxacin tell your doctor if you are using any of the following drugs:

There may be other drugs not listed that can affect moxifloxacin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Your pharmacist has additional information about moxifloxacin written for health professionals that you may read.

Avelox: Dosing

intra-abdominal infxns, complicated:

400 mg PO/IV q24h x5-14 days: Info: start w/ IV form

Avelox: Drug Interactions

Avelox vs antiarrhythmics, class Ia: contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects. Antiarrhythmics, class Ia: also know as disopyramide, procainamide, quinidine gluconate, quinidine sulfate

Avelox vs antiarrhythmics, class III: contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects. Antiarrhythmics, class III: also know as amiodarone, dofetilide, ibutilide, sotalol, sotalol AF

Avelox vs cisapride: contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs phenothiazines: contraindicated for thioridazine, otherwise caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects. Phenothiazines: also know as chlorpromazine, fluphenazine, fluphenazine decanoate, perphenazine, prochlorperazine edisylate, prochlorperazine maleate, prochlorperazine rectal, promethazine, promethazine rectal, thioridazine, trifluoperazine

Avelox vs pimozide: contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs ranolazine: contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs ziprasidone: contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs aminolevulinic acid topical: avoid concurrent use: combo may incr. risk of phototoxicity or augment phototoxic rxn and additive effects

Avelox vs ciprofloxacin: avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects; duplicate tx

Avelox vs clarithromycins: avoid combo or use alternative: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects. Clarithromycins: also know as clarithromycin, lansoprazole/amoxicillin/clarithromycin

Avelox vs erythromycins: avoid combo or use alternative: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects. Erythromycins: also know as erythromycin base, erythromycin ethyl succinate, erythromycin lactobionate, erythromycin stearate, erythromycin/sulfisoxazole

Avelox vs haloperidol: avoid combo or use alternative: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects. Haloperidol: also know as haloperidol, haloperidol decanoate, haloperidol lactate

Avelox vs hydroquinone/retinoid combos: avoid concurrent use: combo may incr. risk of phototoxicity or augment phototoxic rxn and augmented phototoxicity. Hydroquinone/retinoid combos: also know as fluocinolone/hydroquinone/tretinoin topical, mequinol/tretinoin topical

Avelox vs methadone: avoid combo or use alternative: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs methoxsalen: avoid concurrent use: combo may incr. risk of phototoxicity or augment phototoxic rxn and additive effects. Methoxsalen: also know as methoxsalen, methoxsalen topical

Avelox vs paliperidone: avoid combo or use alternative: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs pentamidine: avoid combo or use alternative: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs typhoid vaccine, live oral: avoid combo; delay vaccine until >3 days after abx course complete or complete vaccine >3 days before 1st abx dose: combo may result in inadequate immunologic vaccine response and abx effect may inactivate vaccine

Avelox vs A2R blocker/HCTZ combos: monitor potassium, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias and hypokalemia, other electrolyte abnormalities. A2R blocker/HCTZ combos: also know as candesartan/hydrochlorothiazide, eprosartan/hydrochlorothiazide, hydrochlorothiazide/irbesartan, hydrochlorothiazide/losartan, hydrochlorothiazide/olmesartan, hydrochlorothiazide/valsartan, telmisartan/hydrochlorothiazide

Avelox vs ACE inhibitor/HCTZ combos: monitor potassium, electrolytes: combo w/ thiazides may incr. risk of QT prolongation, cardiac arrhythmias and hypokalemia, other electrolyte abnormalities. ACE inhibitor/HCTZ combos: also know as benazepril/hydrochlorothiazide, captopril/hydrochlorothiazide, enalapril/hydrochlorothiazide, fosinopril/hydrochlorothiazide, hydrochlorothiazide/lisinopril, hydrochlorothiazide/moexipril, hydrochlorothiazide/quinapril

Avelox vs amphotericins: monitor potassium, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias and hypokalemia, other electrolyte abnormalities. Amphotericins: also know as amphotericin B cholesteryl sulfate, amphotericin B deoxycholate, amphotericin B lipid complex, amphotericin B liposomal

Avelox vs antacids: give oral quinolone 2h before gatifloxacin and moxifloxacin 4h before or 4h after aluminum or Mg-containing antacids gemifloxacin 3h after, ciprofloxacin 6h after, enoxacin and moxifloxacin 8h after: combo may decr. quinolone efficacy and absorption decreased. Antacids: also know as aluminum hydroxide, aluminum hydroxide/magnesium hydroxide, aluminum hydroxide/magnesium hydroxide/simethicone

Avelox vs beta blocker/thiazide combos: monitor potassium, electrolytes: combo w/ thiazides may incr. risk of QT prolongation, cardiac arrhythmias and hypokalemia, other electrolyte abnormalities. Beta blocker/thiazide combos: also know as atenolol/chlorthalidone, bendroflumethiazide/nadolol, bisoprolol/hydrochlorothiazide, hydrochlorothiazide/metoprolol, hydrochlorothiazide/propranolol, hydrochlorothiazide/timolol

Avelox vs calcium salts: give oral quinolone 2h before or 4h after calcium salts ciprofloxacin 6h after, enoxacin 8h after; separation not required w/ moxifloxacin, gatifloxacin or gemifloxacin: combo may decr. quinolone efficacy and absorption decreased. Calcium salts: also know as calcium acetate, calcium carbonate, calcium gluconate, risedronate/calcium carbonate

Avelox vs carbonic anhydrase inhibitors, systemic: monitor potassium, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias and hypokalemia, other electrolyte abnormalities. Carbonic anhydrase inhibitors, systemic: also know as acetazolamide, methazolamide

Avelox vs cisplatin: monitor potassium, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias and hypokalemia, other electrolyte abnormalities

Avelox vs corticosteroids, systemic: monitor potassium, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias; tendon rupture and hypokalemia, other electrolyte abnormalities; mechanism unknown. Corticosteroids, systemic: also know as cortisone, dexamethasone, dexamethasone sodium phosphate, hydrocortisone, hydrocortisone sodium succinate, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, prednisolone, prednisone, triamcinolone

Avelox vs didanosine: give oral quinolone 2h before gatifloxacin and moxifloxacin 4h before or 4h after buffered didanosine gemifloxacin 3h after, ciprofloxacin 6h after, enoxacin and moxifloxacin 8h after: combo may decr. quinolone efficacy and absorption decreased

Avelox vs diuretics, loop: monitor potassium, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias and hypokalemia, other electrolyte abnormalities. Diuretics, loop: also know as bumetanide, ethacrynic acid, furosemide, torsemide

Avelox vs diuretics, potassium-sparing/HCTZ: monitor potassium, electrolytes: combo w/ thiazides may incr. risk of QT prolongation, cardiac arrhythmias and hypokalemia, other electrolyte abnormalities. Diuretics, potassium-sparing/HCTZ: also know as amiloride/hydrochlorothiazide, hydrochlorothiazide/spironolactone, hydrochlorothiazide/triamterene

Avelox vs diuretics, thiazide: monitor potassium, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias and hypokalemia, other electrolyte abnormalities. Diuretics, thiazide: also know as chlorothiazide, chlorthalidone, chlorthalidone/clonidine, hydralazine/hydrochlorothiazide, hydrochlorothiazide, indapamide, methyclothiazide, metolazone

Avelox vs exenatide: give oral antibiotic >1h before exenatide: combo may decr. oral antibiotic levels, efficacy and absorption possibly delayed/reduced

Avelox vs foscarnet: monitor potassium, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias and hypokalemia, other electrolyte abnormalities

Avelox vs iron salts, oral: give oral quinolone 2h before gatifloxacin and moxifloxacin 4h before or 4h after iron salts gemifloxacin 3h after, ciprofloxacin 6h after, enoxacin and moxifloxacin 8h after: combo may decr. quinolone levels, efficacy and absorption decreased. Iron salts, oral: also know as ferrous gluconate, ferrous sulfate

Avelox vs quinapril: give quinolone 2h before or 4h after: combo may decr. quinolone efficacy and absorption decreased via chelation

Avelox vs quinolones, QT prolongers: monitor potassium, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias and hypokalemia, other electrolyte abnormalities. Quinolones, QT prolongers: also know as gatifloxacin, gemifloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, ofloxacin

Avelox vs sodium phosphate: monitor electrolytes: combo may incr. risk of seizures, QT prolongation, cardiac arrhythmias and additive effects, electrolyte abnormalities

Avelox vs sucralfate: give oral quinolone 2h before moxifloxacin 4h before or 4h after sulcralfate gemifloxacin 2h after, ciprofloxacin 6h after, enoxacin and moxifloxacin 8h after: combo may decr. quinolone efficacy and absorption decreased

Avelox vs warfarin: monitor INR: combo may incr. INR, risk of bleeding and altered vitamin K production by gut flora

Avelox vs abarelix: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs acetaminophen/tramadol: caution advised: combo w/ tramadol may incr. risk of seizures and additive effects

Avelox vs apomorphine: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs azithromycin: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs beta 2 agonists, all: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and cardiovascular adrenergic effects, hypokalemia. Beta 2 agonists, all: also know as albuterol, albuterol inhaled, albuterol/ipratropium inhaled, arformoterol inhaled, budesonide/formoterol inhaled, fluticasone/salmeterol inhaled, formoterol inhaled, isoproterenol, levalbuterol inhaled, metaproterenol, pirbuterol inhaled, salmeterol inhaled, terbutaline

Avelox vs bupropion: caution advised: combo may incr. risk of seizures and additive effects

Avelox vs clozapine: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias, seizures and additive effects

Avelox vs contraceptives, oral combo: caution advised: abx may decr. hormonal contraceptive efficacy; best evid. for tetracyclines, ampicillin and enterohepatic recirculation possibly altered. Contraceptives, oral combo: also know as desogestrel/ethinyl estradiol, drospirenone/ethinyl estradiol, ethinyl estradiol/ethynodiol, ethinyl estradiol/levonorgestrel, ethinyl estradiol/norethindrone, ethinyl estradiol/norgestimate, ethinyl estradiol/norgestrel, mestranol/norethindrone

Avelox vs contraceptives, oral progestin: caution advised: abx may decr. hormonal contraceptive efficacy; best evid. for tetracyclines, ampicillin and enterohepatic recirculation possibly altered. Contraceptives, oral progestin: also know as norethindrone, norgestrel

Avelox vs dasatinib: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs diclofenac topical: caution advised: combo may incr. risk of CNS stimulation, seizures and mechanism unknown; up to 10% systemic absorption of diclofenac topical gel; minimal absorption w/ patch. Diclofenac topical: also know as diclofenac epolamine topical, diclofenac topical

Avelox vs dolasetron: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs droperidol: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs flecainide: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs fluconazole: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs hydrocodone/ibuprofen: caution advised: combo may incr. risk of CNS stimulation, seizures and mechanism unknown

Avelox vs ibuprofen/oxycodone: caution advised: combo may incr. risk of CNS stimulation, seizures and mechanism unknown

Avelox vs lansoprazole/naproxen: caution advised: combo may incr. risk of CNS stimulation, seizures and mechanism unknown

Avelox vs lapatinib: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs lindane topical: caution advised: combo may incr. risk of seizures and additive toxicity

Avelox vs mefloquine: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and mechanism unknown, possible additive effects

Avelox vs meperidine/promethazine: caution advised: combo w/ phenothiazines may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs mycophenolate mofetil: caution advised: combo may decr. mycophenolate efficacy and enterohepatic recirculation decreased

Avelox vs mycophenolic acid: caution advised: combo may decr. mycophenolic acid efficacy and enterohepatic recirculation decreased

Avelox vs NSAIDs: caution advised: combo may incr. risk of CNS stimulation, seizures and mechanism unknown. NSAIDs: also know as diclofenac potassium, diclofenac sodium, diclofenac/misoprostol, diflunisal, etodolac, fenoprofen, flurbiprofen, ibuprofen, ibuprofen lysine, indomethacin, ketoprofen, ketorolac, meclofenamate, mefenamic acid, meloxicam, nabumetone, naproxen, naproxen sodium, oxaprozin, piroxicam, sulindac, tolmetin

Avelox vs posaconazole: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs promethazine/codeine: caution advised: combo w/ phenothiazines may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs propafenone: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs quetiapine: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs solifenacin: caution advised: combo may risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs tacrolimus: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs tamoxifen: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs telithromycin: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs tiagabine: caution advised, especially in non-epileptic pts: combo may incr. risk of seizures and additive effects

Avelox vs tramadol: caution advised: combo may incr. risk of seizures and additive effects

Avelox vs tricyclic antidepressants: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects. Tricyclic antidepressants: also know as amitriptyline, amitriptyline/chlordiazepoxide, amitriptyline/perphenazine, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, trimipramine

Avelox vs venlafaxine: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs voriconazole: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox vs vorinostat: caution advised: combo may incr. risk of QT prolongation, cardiac arrhythmias and additive effects

Avelox: Adverse Reactions

anaphylaxis

hypersensitivity rxn

phototoxicity

pseudomembranous colitis

superinfection

incr. ICP

seizures

toxic psychosis

depression

suicidal ideation (rare)

skin rxns, severe (rare)

vasculitis (rare)

serum sickness (rare)

pneumonitis, allergic (rare)

myelosuppression (rare)

blood dyscrasias (rare)

nephrotoxicity (rare)

hepatotoxicity, incl. fatal (rare)

QT prolongation (rare)

torsades de pointes (rare)

peripheral neuropathy (rare)

tendon rupture (rare)

arthropathy (animal studies)

nausea

diarrhea

dizziness

Did you know?

Yes, Avelox today sold under many names; here is only few:

→ Moxifloxacin
→ Avalox
→ Vigamox

Buy any from these brand names you receice medicine contain same active ingredient as contain original Avelox

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