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Manufacturer of Benadryl

McNeil-PPC, Inc.

Also know under brand names: 40 Winks, Aler-Dryl, Banophen, Benadryl, Calm-Aid, Compoz Nighttime Sleep Aid, Diphedryl, Diphen, Genahist, Hydramine, Nu-Med, Nytol Caplet, Quenalin, Scot-Tussin Allergy Relief Formula, Sleep, Sleepinal, Sominex, Twilite, Unisom Sleepgels Maximum Strength

Active ingredient / generic name: diphenhydramine

Approximate US Retail Price for Benadryl

Short leaflet

Severe:

Urogenital and reproductive:

Benadryl hydrochloride (trade name Benadryl as produced by Johnson & Johnson, or Dimedrol outside the U.S. & Canada. Nytol as a sleeping pill) is an over-the-counter (OTC) antihistamine, antiemetic, sedative and hypnotic. It may also be used for the treatment of extrapyramidal side effects of typical antipsychotics. It is a member of the ethanolamine class of antihistaminergic agents.

Benadryl is an anticholinergic, possessing 58 per cent of the anti-muscarinic power of atropine and was discovered during the search for synthetic alternatives to scopolamine which would be easier to work with.

Benadryl was one of the first known antihistamines, invented in 1943 by Dr. George Rieveschl. It became the first FDA-approved prescription antihistamine in 1946.

The brand Benadryl is currently trademarked in the United States by Pfizer, however many drug store chains and retail outlets manufacture less-costly generic versions under their own store brands.

Benadryl works by blocking the effect of histamine at H₁ receptor sites. This results in effects such as the reduction of smooth muscle contraction, making Benadryl a popular choice for treatment of the symptoms of allergic rhinitis, hives, motion sickness, and insect bites and stings.

In the 1960s it was found that Benadryl inhibits reuptake of the neurotransmitter serotonin. This discovery led to a search for viable antidepressants with similar structures and fewer side effects, culminating in the invention of fluoxetine (Prozac), a selective serotonin reuptake inhibitor (SSRI). A similar search had previously led to the synthesis of the first SSRI zimelidine from chlorpheniramine, also an antihistamine.

Benadryl is a first-generation antihistamine drug. Despite being one of the oldest antihistamines on the market, it is largely the most effective antihistamine available either by prescription or over-the-counter, and has been shown to exceed the effectiveness of even the latest prescription drugs. Consequently, it is frequently used when an allergic reaction requires fast, effective reversal of the often dangerous effects of a massive histamine release. However, it is not always the drug of choice for treating allergies.

It is known that Benadryl has sedative properties. Many new antihistamines have been introduced without the side effect of sedation. The drug is also used as a sleep aid and is an ingredient in many sleep aids, such as Unisom gelcaps (however, the tablet form of Unisom contains Doxylamine, a different active ingredient), and most notably Tylenol PM where it is combined with acetaminophen (paracetamol), and Nytol and Sominex which have Benadryl as the only active ingredient. Several generic and store brands of antihistamines and sleep aids also contain solely Benadryl, such as Tylenol Simply Sleep.

Benadryl is widely used in nonprescription sleep aids with a maximum recommended dose of 50mg (as the hydrochloride salt) being mandated by the FDA. In the United Kingdom, Australia, New Zealand, South Africa, and other countries, a 50 to 100mg recommended dose is permitted, though in the case of New Zealand the purchaser is required to provide the pharmacist with their name, address and other personal identification to be later logged in a national police data base following any purchase of over the counter medications containing Benadryl such as Unisom.

There are also topical formulations of Benadryl available, including creams, lotions, gels, and sprays. They are used to relieve itching, and have the advantage of causing much less systemic effect (i.e. drowsiness) than oral forms.

Like many other first-generation antihistamines, Benadryl is a potent anticholinergic agent. This leads to profound drowsiness as a very common side-effect, along with the possibilities of motor impairment (ataxia), dry mouth and throat, flushed skin, rapid or irregular heartbeat (tachycardia), blurred vision at nearpoint owing to lack of accommodation (cycloplegia), abnormal sensitivity to bright light (photophobia), pupil dilation (mydriasis), urinary retention (ischuria), constipation, difficulty concentrating, short-term memory loss, visual disturbances, hallucinations, irritability, itchy skin, confusion, erectile dysfunction, and delirium. Some side effects such as twitching may be delayed until the drowsiness begins to cease and the person is in more of an awakening mode. Benadryl also has local anesthetic properties, and has been used for patients allergic to common local anesthetics like lidocaine. Severe, prolonged twitching and muscle spasm have also been experienced.

The most common cardiac dysrhythmias associated with Benadryl overdose are sinus bradycardia, elongated S-T segment interval, and premature ventricular contraction.

Benadryl is similar in its effects to dimenhydrinate (Dramamine), its 8-chlorotheophylline salt, although the latter is approximately 60% the potency in terms of required dosage and is slightly less sedating.

Some patients have an allergic reaction to Benadryl in the form of hives.

Benadryl is used both clinically and recreationally in conjunction with opioids to relieve itching and act as an analgesia potentiator in a dose of 10-75 mg depending on body size and length of Benadryl use. It is used recreationally as a deliriant, depressant, or booster for alcohol. Mixing medications with sedating antihistamines other than under medical supervision can be quite dangerous.

Those who use Benadryl recreationally take a higher dose than recommended. The mental effects are described by many as "dreaming while awake" involving visual and auditory hallucinations that, unlike those experienced with most psychedelic drugs, often cannot be readily distinguished from reality. People who consume a high recreational dose can possibly find themselves in a hallucination which places them in a familiar situation with people and friends and rooms they know, while in reality being in a totally different setting. Inexperienced users of hallucinogens are liable to panic.

Many users report a side effect profile consistent with tropane glycoalkaloidal poisoning. This is due to antagonism of muscarinic acetylcholine receptors in both the central and autonomic nervous system which inhibits various signal transduction pathways. In the CNS, Benadryl readily crosses the blood-brain barrier, exerting effects within the visual and auditory cortex.

Other CNS effects occur within the limbic system and hippocampus, causing confusion and temporary amnesia. Toxicology also manifests in the autonomic nervous system, primarily at the neuromuscular junction, resulting in ataxia and extrapyramidal side-effects, and at sympathetic post-ganglionic junctions, causing urinary retention, pupil dilation, tachycardia, irregular urination, and dry skin and mucous membranes. Considerable overdosage can lead to myocardial infarction (heart attack), serious ventricular dysrhythmias, coma and death. Such a side-effect profile is thought to give ethanolamine-class antihistamines a relatively low abuse liability. The specific antidote for Benadryl poisoning is physostigmine, usually given by IV in hospital.

Benadryl: Patient Education

Use caution when driving, operating machinery, or performing other hazardous activities. Diphenhydramine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking diphenhydramine.

Diphenhydramine is an antihistamine. Diphenhydramine blocks the effects of the naturally occurring chemical histamine in the body.

Diphenhydramine is used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold.

Diphenhydramine is also used to suppress coughs, to treat motion sickness, to induce sleep, and to treat mild forms of Parkinson's disease.

Diphenhydramine may also be used for purposes other than those listed in this medication guide.

Do not take diphenhydramine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects.

Before taking this medication, tell your doctor if you have

Diphenhydramine is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take diphenhydramine without first talking to your doctor if you are pregnant.

Infants are especially sensitive to the effects of antihistamines, and side effects could occur in a breast-feeding baby. Do not take diphenhydramine without first talking to your doctor if you are nursing a baby.

If you are over 60 years of age, you may be more likely to experience side effects from diphenhydramine. You may require a lower dose of this medication.

Take diphenhydramine exactly as directed on the package or as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Diphenhydramine can be taken with or without food.

For motion sickness, a dose is usually taken 30 minutes before motion, then with meals and at bedtime for the duration of exposure.

As a sleep aid, diphenhydramine should be taken approximately 30 minutes before bedtime.

To ensure that you get a correct dose, measure the liquid forms of diphenhydramine with a special dose-measuring spoon or cup, not with a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Never take more of this medication than is prescribed for you. The maximum amount of diphenhydramine that you should take in any 24-hour period is 300 mg.

Store diphenhydramine at room temperature away from moisture and heat.

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.

Seek emergency medical attention if an overdose is suspected.

Symptoms of a diphenhydramine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures.

Use caution when driving, operating machinery, or performing other hazardous activities. Diphenhydramine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking diphenhydramine.

Stop taking diphenhydramine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to take diphenhydramine and talk to your doctor if you experience

Do not take diphenhydramine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects.

Talk to your pharmacist before taking other over-the-counter cough, cold, allergy, or insomnia medications. These products may contain medicines similar to diphenhydramine, which could lead to an antihistamine overdose.

Before taking this medication, tell your doctor if you are taking any of the following medicines:

Your pharmacist has more information about diphenhydramine written for health professionals that you may read.

Diphenhydramine is available with a prescription and over the counter generically and under many brand names as tablets, capsules, an elixir, and a syrup. Other formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Benadryl: Dosing

upper respiratory sx:

25-50 mg PO q4-6h prn: Max: 100 mg/dose; 400 mg/day

allergic rxns, mod-severe:

25-50 mg PO q2-4h prn: Max: 100 mg/dose; 400 mg/day

extrapyramidal sx:

25-50 mg PO q6-8h prn: Max: 100 mg/dose; 400 mg/day

insomnia, short-term tx:

25-50 mg PO qhs prn: Info: give 30min before bedtime

motion sickness prevention:

25-50 mg PO q4-6h prn: Max: 300 mg/day; Info: start 30min before motion exposure

sedation:

25-50 mg PO q4-6h prn: Max: 300 mg/day

renal dosing:

no adjustment: HD/CAPD: no supplement

Benadryl: Drug Interactions

Benadryl vs potassium salts: contraindicated for solid potassium dose forms; weigh risk/benefit of thyroid protection w/ solid iodide salt forms; use alternative dose forms: combo may delay solid potassium passage through GI tract, incr. risk of ulcerative/stenotic lesions and anticholinergics slow GI transit, incr. local exposure to high potassium concentration. Potassium salts: also know as potassium acid phosphate, potassium acid phosphate/sodium acid phosphate, potassium chloride, potassium citrate, potassium iodide, potassium phosphate, potassium phosphate/sodium phosphate, potassium phosphate/sodium phosphates, dibasic and monobasic

Benadryl vs haloperidol: avoid combo or use alternative: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, anticholinergic adverse effects and hepatic metab. inhibited, additive effects. Haloperidol: also know as haloperidol, haloperidol decanoate, haloperidol lactate

Benadryl vs MAOIs, all: avoid combo w/in 14 days of MAO inhibitor use: combo may prolong and intensify anticholinergic effects of antihistamines and mechanism unknown. MAOIs, all: also know as isocarboxazid, phenelzine, procarbazine, rasagiline, selegiline, selegiline transdermal, tranylcypromine

Benadryl vs pramlintide: avoid or use alternative: combo w/ anticholinergic agents may further delay gastric emptying/slow GI transit and additive effects

Benadryl vs sodium oxybate: avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, adverse effects and additive effects

Benadryl vs dexmedetomidine: caution advised, consider dose reduction: combo may incr. risk of CNS depression, adverse effects and additive effects

Benadryl vs acetaminophen/butalbital: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects

Benadryl vs acetaminophen/caffeine/CNS depressant combos: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects. Acetaminophen/caffeine/CNS depressant combos: also know as acetaminophen/butalbital/caffeine, acetaminophen/butalbital/caffeine/codeine, acetaminophen/caffeine/dihydrocodeine

Benadryl vs acetaminophen/opiate combos: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, other adverse effects and additive/synergistic effects. Acetaminophen/opiate combos: also know as acetaminophen/codeine, acetaminophen/hydrocodone, acetaminophen/oxycodone, acetaminophen/pentazocine

Benadryl vs acetaminophen/propoxyphene: caution advised: combo w/ propoxyphene may incr. risk of CNS depression, psychomotor impairment and additive effects. Acetaminophen/propoxyphene: also know as acetaminophen/propoxyphene HCl, acetaminophen/propoxyphene napsylate

Benadryl vs acetaminophen/tramadol: caution advised: combo w/ tramadol may incr. risk of CNS depression, psychomotor impairment and additive effects

Benadryl vs anticholinergics: caution advised: combo may incr. anticholinergic adverse effects and additive effects. Anticholinergics: also know as amantadine, atropine, atropine/benzoic acid/hyoscyamine/methenamine/methylene blue/phenyl salicylate, atropine/hyoscyamine/phenobarbital/scopolamine, benztropine, biperiden, chlordiazepoxide/clidinium, dicyclomine, difenoxin/atropine, diphenoxylate/atropine, flavoxate, glycopyrrolate, hyoscyamine, methscopolamine, oxybutynin, oxybutynin transdermal, propantheline, scopolamine, scopolamine transdermal, tolterodine, trihexyphenidyl, trospium

Benadryl vs anticholinergics, ophthalmic: caution advised: combo may incr. anticholinergic adverse effects and additive effects. Anticholinergics, ophthalmic: also know as atropine ophthalmic, cyclopentolate ophthalmic, homatropine ophthalmic, scopolamine ophthalmic, tropicamide ophthalmic

Benadryl vs antidepressants, other: caution advised: combo may incr. risk of CNS depression and additive effects. Antidepressants, other: also know as maprotiline, mirtazapine, nefazodone, trazodone

Benadryl vs antihist/decongest/DM combos: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects and additive effects. Antihist/decongest/DM combos: also know as brompheniramine/dextromethorphan/pseudoephedrine, chlorpheniramine/phenylephrine/dextromethorphan

Benadryl vs antihist/decongestant combos: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic and other adverse effects and additive effects, duplicate antihistamine tx. Antihist/decongestant combos: also know as acrivastine/pseudoephedrine, brompheniramine/phenylephrine, chlorpheniramine/phenylephrine, chlorpheniramine/pseudoephedrine, pseudoephedrine/triprolidine

Benadryl vs antihistamines, sedating: caution advised: combo may incr. risk of CNS depression, anticholinergic and other adverse effects and additive effects. Antihistamines, sedating: also know as brompheniramine, carbinoxamine, chlorpheniramine, clemastine fumarate, cyproheptadine, dimenhydrinate, diphenhydramine, hydroxyzine, meclizine

Benadryl vs apomorphine: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects

Benadryl vs aripiprazole: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects and additive effects

Benadryl vs aspirin/caffeine/CNS depressant combos: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects. Aspirin/caffeine/CNS depressant combos: also know as aspirin/butalbital/caffeine, aspirin/butalbital/caffeine/codeine, aspirin/caffeine/dihydrocodeine

Benadryl vs aspirin/caffeine/orphenadrine: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects and additive effects

Benadryl vs aspirin/muscle relaxant combos: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects. Aspirin/muscle relaxant combos: also know as aspirin/carisoprodol

Benadryl vs aspirin/opiate combos: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects. Aspirin/opiate combos: also know as aspirin/carisoprodol/codeine, aspirin/codeine, aspirin/oxycodone

Benadryl vs azelastine nasal: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects

Benadryl vs barbiturates: caution advised: combo may incr. risk of CNS depression and additive effects. Barbiturates: also know as butabarbital, methohexital, pentobarbital, phenobarbital, primidone, secobarbital, thiopental

Benadryl vs BZDs, all: caution advised: combo may incr. risk of CNS depression and additive effects. BZDs, all: also know as alprazolam, chlordiazepoxide, clonazepam, clorazepate, diazepam, diazepam rectal, estazolam, flurazepam, lorazepam, midazolam, oxazepam, temazepam, triazolam

Benadryl vs cannabinoids: caution advised: combo may incr. risk of tachycardia, drowsiness, CNS depression, psychomotor impairment and additive/synergistic effects. Cannabinoids: also know as dronabinol, nabilone

Benadryl vs central alpha 2 agonists: caution advised: combo may incr. risk of CNS depression and additive effects. Central alpha 2 agonists: also know as clonidine, clonidine transdermal, guanabenz, guanfacine, methyldopa

Benadryl vs cetirizine: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects. Cetirizine: also know as cetirizine, cetirizine/pseudoephedrine

Benadryl vs chlorpheniramine/hydrocodone: caution advised: combo may incr. risk of CNS depression, psychomotor impairment; some antihistamines may potentiate opioid analgesic effects and additive/synergistic effects

Benadryl vs cholinergic agents: caution advised: combo may decr. efficacy of both and antagonistic effects. Cholinergic agents: also know as bethanechol, cevimeline, pilocarpine

Benadryl vs cholinergic agents, ophthalmic: caution advised: combo may decr. efficacy of ophthalmic cholinergic agent and antagonistic effects. Cholinergic agents, ophthalmic: also know as carbachol ophthalmic, pilocarpine ophthalmic

Benadryl vs clozapine: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects and additive effects

Benadryl vs cyclopentolate/phenylephrine ophthalmic: caution advised: combo may incr. anticholinergic adverse effects and additive effects

Benadryl vs dantrolene: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects

Benadryl vs darifenacin: caution advised: combo may incr. anticholinergic adverse effects and additive effects

Benadryl vs decongest/opiate combos: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects. Decongest/opiate combos: also know as guaifenesin/hydrocodone/phenylephrine

Benadryl vs disopyramide: caution advised: combo may incr. anticholinergic adverse effects and additive effects

Benadryl vs doxazosin: caution advised w/ XL dosage form: combo may incr. doxazosin levels, risk of adverse effects and absorption increased, slower GI transit due to anticholinergic effects

Benadryl vs droperidol: caution advised: combo may incr. risk of CNS depression and additive effects

Benadryl vs ethanol: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects

Benadryl vs ethosuximide: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects

Benadryl vs levocetirizine: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects

Benadryl vs loxapine: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects and additive effects

Benadryl vs meperidine/promethazine: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, other adverse effects and additive effects

Benadryl vs meprobamate: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects

Benadryl vs methadone: caution advised, consider opioid dose reduction: combo may incr. risk of severe constipation/paralytic ileus, CNS depression, psychomotor impairment, other adverse effects and additive effects

Benadryl vs metoclopramide: caution advised: combo may decr. GI prokinetic effects, incr. risk of CNS depression and antagonistic effects, additive effects

Benadryl vs mitotane: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects

Benadryl vs molindone: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects and additive effects

Benadryl vs morphine liposomal: caution advised: combo may incr. risk of CNS depression, profound sedation, other adverse effects and additive effects

Benadryl vs muscle relaxants: caution advised: combo may incr. risk of CNS depression and additive effects. Muscle relaxants: also know as baclofen, baclofen intrathecal, carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, orphenadrine, tizanidine

Benadryl vs olanzapine: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects and additive effects

Benadryl vs olanzapine/fluoxetine: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects and additive effects

Benadryl vs opiate agonist/antagonists: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects. Opiate agonist/antagonists: also know as buprenorphine, buprenorphine/naloxone, butorphanol, butorphanol nasal, nalbuphine, pentazocine lactate, pentazocine/naloxone

Benadryl vs opiates: caution advised, consider opioid dose reduction: combo may incr. risk of severe constipation/paralytic ileus, CNS depression, psychomotor impairment, other adverse effects and additive effects. Opiates: also know as alfentanil, codeine phosphate, codeine sulfate, codeine/guaifenesin, fentanyl, fentanyl buccal, fentanyl oral transmucosal, fentanyl transdermal, guaifenesin/hydrocodone, hydrocodone/homatropine, levorphanol, meperidine, morphine sulfate, oxycodone, oxymorphone, remifentanil, sufentanil

Benadryl vs oxcarbazepine: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects

Benadryl vs paliperidone: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects and additive effects

Benadryl vs phenothiazines: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects and additive effects. Phenothiazines: also know as chlorpromazine, fluphenazine, fluphenazine decanoate, perphenazine, prochlorperazine edisylate, prochlorperazine maleate, prochlorperazine rectal, promethazine, promethazine rectal, thioridazine, trifluoperazine

Benadryl vs pimozide: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects and additive effects

Benadryl vs pramipexole: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects

Benadryl vs pregabalin: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, adverse effects and additive effects

Benadryl vs promethazine/codeine: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects and additive effects

Benadryl vs propoxyphene: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects. Propoxyphene: also know as propoxyphene HCl, propoxyphene napsylate

Benadryl vs quetiapine: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects and additive effects

Benadryl vs risperidone: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects and additive effects

Benadryl vs ropinirole: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects

Benadryl vs rotigotine transdermal: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects

Benadryl vs sedative/hypnotics: caution advised: combo may incr. risk of CNS depression and additive effects. Sedative/hypnotics: also know as chloral hydrate, chloral hydrate rectal, eszopiclone, zaleplon, zolpidem

Benadryl vs solifenacin: caution advised: combo may incr. anticholinergic adverse effects and additive effects

Benadryl vs thalidomide: caution advised: combo may incr. risk of CNS depression and additive effects

Benadryl vs thiothixene: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects and additive effects

Benadryl vs tiagabine: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects

Benadryl vs tramadol: caution advised: combo may incr. risk of CNS depression, psychomotor impairment; combo w/ diphenhydramine may incr. tramadol or decr. metabolite levels, incr. toxicity or alter efficacy and additive effects; hepatic metab. inhibited, decr. conversion to active metabolite

Benadryl vs tricyclic antidepressants: caution advised: combo may incr. risk of CNS depression, anticholinergic and other adverse effects and additive effects. Tricyclic antidepressants: also know as amitriptyline, amitriptyline/chlordiazepoxide, amitriptyline/perphenazine, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, trimipramine

Benadryl vs valproic acid derivatives: caution advised: combo may incr. risk of CNS depression, psychomotor impairment and additive effects. Valproic acid derivatives: also know as divalproex sodium, valproate sodium, valproic acid

Benadryl vs ziconotide intrathecal: caution advised: combo may incr. risk of confusion, dizziness, other CNS adverse effects and additive effects

Benadryl vs ziprasidone: caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects and additive effects

Benadryl vs zonisamide: caution advised: combo w/ drugs possessing anticholinergic effects may incr. risk of oligohydrosis, hyperthermia, and heat stroke especially in children and additive effects

Benadryl: Adverse Reactions

hypotension

wheezing

anticholinergic toxicity

convulsions

labyrinthitis, acute

neuritis

hemolytic anemia (rare)

thrombocytopenia (rare)

agranulocytosis (rare)

anaphylactoid rxns (rare)

sedation

dizziness

coordination problems

thickened bronchial secretions

dry mucous membranes

blurred vision

paradoxical CNS stimulation

nasal stuffiness

constipation

palpitations/tachycardia

urinary retention

epigastric discomfort

anorexia

confusion

incr. sweating

tremor

chest tightness

tinnitus

rash/urticaria

photosensitivity

Did you know?

Yes, Benadryl today sold under many names; here is only few:

→ Diphenhydramine
→ Dimedrol
→ Nytol

Buy any from these brand names you receice medicine contain same active ingredient as contain original Benadryl

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