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Manufacturer of Coreg

GlaxoSmithKline

Also know under brand names: Coreg, Coreg CR

Active ingredient / generic name: carvedilol

Approximate US Retail Price for Coreg

3.125 mg (60 ea): $131.99
6.25 mg (30 ea): $70.99
12.5 mg (60 ea): $136.00
25 mg (60 ea): $136.00

Short leaflet

Coreg is a non-selective beta blocker indicated in the treatment of mild to moderate congestive heart failure (CHF). It is marketed under various trade names including Coreg (GSK), Dilatrend (Roche) and Eucardic (Roche), as a generic drug (as of September 5, 2007 in the U.S.)., and as a controlled-release formulation, marketed in the US as Coreg CR (GSK).

Norepinephrine stimulates the nerves that control the muscles of the heart by binding to the β₁- and β₂-adrenergic receptors. Coreg blocks the binding to those receptors, which both slows the heart rhythm and reduces the force of the heart's pumping. This lowers blood pressure and reduces heart failure. Norepinephrine also binds to the α₁-adrenergic receptors on blood vessels, causing them to constrict and raise blood pressure. Coreg blocks this binding to the α₁-adrenergic receptors too, which also lowers blood pressure.

Relative to other beta blockers, Coreg has minimal inverse agonist activity (Vanderhoff et al., 1998). This suggests that Coreg has a reduced negative chronotropic and inotropic effect compared to other beta blockers, which may decrease its potential to worsen symptoms of heart failure. However, to date this theoretical benefit has not been established in clinical trials, and the current version of the ACC/AHA guidelines on congestive heart failure management does not give preference to Coreg over other beta-blockers.

Coreg is indicated in the management of congestive heart failure (CHF), as an adjunct to conventional treatments (ACE inhibitors and diuretics). The use of Coreg has been shown to provide additional morbidity and mortality benefits in CHF (Packer et al., 2002).

On January 10, 2006 Coreg supply became limited in the United States, due to changes in documentation procedures at a plant. This was lifted in April 27, 2006 in a Dear Pharmacist letter. [1]

On October 20, 2006, the FDA approved a controlled release formulation of Coreg, to be marketed as Coreg CR.

Coreg: Patient Education

Do not stop taking carvedilol without first talking to your doctor. Stopping suddenly may make your condition worse.

If you need to have any type of surgery, you may need to temporarily stop using carvedilol. Be sure the surgeon knows ahead of time that you are using carvedilol.

Carvedilol can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol within 2 hours before or after taking extended-release carvedilol (Coreg CR). Also avoid taking medicines or other products that might contain alcohol. Alcohol may cause the carvedilol in Coreg CR to be released too quickly into the body.

Carvedilol is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely if you are being treated for hypertension.

Hypertension often has no symptoms, so you may not even feel that you have high blood pressure. Continue using this medicine as directed, even if you feel well. You may need to use blood pressure medication for the rest of your life.

Carvedilol is in a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).

Carvedilol is used to treat heart failure and hypertension (high blood pressure). It is also used to treat or prevent heart attack.

Carvedilol may also be used for purposes other than those listed in this medication guide.

Before taking carvedilol, tell your doctor if you have:

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether carvedilol passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Take carvedilol exactly as it was prescribed for you. Do not take the medication in larger amounts or for longer than recommended by your doctor. Follow the directions on your prescription label.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Take this medication with a full glass of water.

Take carvedilol at the same time every day. Do not skip doses or stop taking carvedilol without first talking to your doctor. Stopping suddenly may make your condition worse.

Do not crush, chew, break, or open an extended-release capsule. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time.

If you are switched from carvedilol tablets to carvedilol extended-release capsules, your daily total dose of this medicine may be higher or lower than before. Follow your doctor's instructions.

To be sure this medication is helping your condition, your blood pressure will need to be checked on a regular basis. It is important that you not miss any scheduled visits to your doctor.

If you need to have any type of surgery, tell the surgeon that you are using carvedilol. You may need to briefly stop using carvedilol before having surgery.

Carvedilol is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely if you are being treated for hypertension.

Hypertension often has no symptoms, so you may not even feel that you have high blood pressure. Continue using this medicine as directed, even if you feel well. You may need to use blood pressure medication for the rest of your life.

Store carvedilol at room temperature away from moisture and heat.

Take the missed dose as soon as you remember. If your next dose is less than 4 hours away, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a carvedilol overdose may include uneven heartbeats, shortness of breath, bluish-colored fingernails, dizziness, weakness, fainting, or seizure (convulsions).

Carvedilol can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol within 2 hours before or after taking extended-release carvedilol (Coreg CR). Also avoid taking medicines or other products that might contain alcohol. Alcohol may cause the carvedilol in Coreg CR to be released too quickly into the body. Check the labels of any prescription or over-the-counter medicines you take to see if they contain alcohol (also called ethanol).

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

Before taking carvedilol, tell your doctor if you are using:

There may be other drugs not listed that can affect carvedilol. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Your pharmacist has additional information about carvedilol written for health professionals that you may read.

Coreg: Dosing

HTN:

6.25-25 mg PO bid: Start: 6.25 mg bid, incr. q1-2wk to 12.5 mg bid, then 25 mg bid prn; Max: 25 mg bid; Info: give w/ food; taper dose over 1-2wk to D/C

CHF:

6.25-25 mg PO bid: Start: 3.125 mg bid, incr. q2wk to 6.25 mg bid, then 12.5 mg bid, then 25 mg bid; Max: 25 mg bid; 50 mg bid if >85 kg; Info: minimize fluid retention prior to tx; give w/ food; taper dose over 1-2wk to D/C

cardiovascular event prevention, post-MI:

25 mg PO bid: Start: 6.25 mg PO bid, incr. q3-10 days to 12.5 mg bid, then 25 mg bid; Info: for pts w/ <41% LVEF; minimize fluid retention prior to tx; start ASAP after pt stable; start 3.125 mg bid and/or titrate slower if fluid retention, hypotension, or bradycardia; give w/ food; taper dose over 1-2wk to D/C

renal dosing:

no adjustment: HD/CAPD: no supplement

hepatic dosing:

see below: hepatic impairment: avoid use

Coreg: Drug Interactions

Coreg vs central alpha 2 agonists: use alternative or monitor BP, D/C beta blocker first: combo may decr. antihypertensive response to alpha 2 agonist, incr. risk of severe rebound HTN on alpha 2 agonist withdrawal and antagonistic effects, unopposed alpha adrenergic stimulation. Central alpha 2 agonists: also know as clonidine, clonidine transdermal, guanabenz, guanfacine, methyldopa

Coreg vs cimetidine: use alternative or non-hepatically metabolized beta blocker e.g. atenolol, nadolol: combo may incr. risk of bradycardia, hypotension and hepatic metab. inhibited

Coreg vs cocaine topical: avoid combo: combo may result in unopposed alpha-adrenergic stimulation w/ incr. risk of HTN, severe vasoconstriction, arrhythmias and additive effects

Coreg vs COX 2 inhibitors: monitor BP, use alternative: combo may cause sodium/water retention, decr. antihypertensive efficacy and antagonistic effects. COX 2 inhibitors: also know as celecoxib

Coreg vs fenoldopam: avoid combo: combo may incr. risk of hypotension and beta blocker interference w/ reflex tachycardia; additive effects

Coreg vs hydrocodone/ibuprofen: monitor BP, consider alternatives: combo may decr. antihypertensive efficacy and antagonistic effect due to NSAID-induced inhibition of renal prostaglandins, sodium and fluid retention

Coreg vs ibuprofen/oxycodone: monitor BP, consider alternatives: combo may decr. antihypertensive efficacy and antagonistic effect due to NSAID-induced inhibition of renal prostaglandins, sodium and fluid retention

Coreg vs insulins: use alternative: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism. Insulins: also know as insulin aspart, insulin aspart protamine/insulin aspart, insulin detemir, insulin glargine, insulin glulisine, insulin inhaled, insulin lispro, insulin lispro protamine/insulin lispro, insulin NPH, insulin NPH/regular, insulin regular

Coreg vs lansoprazole/naproxen: monitor BP, consider alternatives: combo w/ NSAIDs may cause sodium/water retention, decr. antihypertensive efficacy and antagonistic effects

Coreg vs NSAIDs: monitor BP, consider alternatives: combo may decr. antihypertensive efficacy and antagonistic effect due to NSAID-induced inhibition of renal prostaglandins, sodium and fluid retention. NSAIDs: also know as diclofenac potassium, diclofenac sodium, diclofenac/misoprostol, diflunisal, etodolac, fenoprofen, flurbiprofen, ibuprofen, ibuprofen lysine, indomethacin, ketoprofen, ketorolac, meclofenamate, mefenamic acid, meloxicam, nabumetone, naproxen, naproxen sodium, oxaprozin, piroxicam, sulindac, tolmetin

Coreg vs acetaminophen/propoxyphene: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, other adverse effects and hepatic metab. inhibited. Acetaminophen/propoxyphene: also know as acetaminophen/propoxyphene HCl, acetaminophen/propoxyphene napsylate

Coreg vs alpha 2 agonists, ophthalmic: caution advised, monitor BP, HR: combo may incr. risk of hypotension, bradycardia, AV block and additive effects. Alpha 2 agonists, ophthalmic: also know as apraclonidine ophthalmic, brimonidine ophthalmic

Coreg vs alpha 2 agonists/beta blockers, ophthalmic: caution advised, monitor BP, HR, IOP: combo may incr. risk of hypotension, bradycardia, AV block, decr. IOP and additive effects. Alpha 2 agonists/beta blockers, ophthalmic: also know as brimonidine/timolol ophthalmic

Coreg vs amiodarone: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, sinus arrest, AV block, other adverse effects and hepatic metab. inhibited; additive effects

Coreg vs amitriptyline/perphenazine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited; additive hypotensive effects

Coreg vs antihist/decongestant combos: caution advised, monitor BP: combo w/ decongestants may decr. antihypertensive efficacy and antagonistic effects. Antihist/decongestant combos: also know as acrivastine/pseudoephedrine, brompheniramine/phenylephrine, chlorpheniramine/phenylephrine, chlorpheniramine/pseudoephedrine, pseudoephedrine/triprolidine

Coreg vs aspirin/butalbital/caffeine: caution advised, monitor BP: combo w/ high dose aspirin or salicylates may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention

Coreg vs aspirin/butalbital/caffeine/codeine: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention

Coreg vs aspirin/caffeine/dihydrocodeine: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive efficacy and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention

Coreg vs aspirin/caffeine/orphenadrine: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention

Coreg vs aspirin/dipyridamole: caution advised, monitor BP: combo w/ high dose aspirin or salicylates may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention

Coreg vs aspirin/muscle relaxant combos: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention. Aspirin/muscle relaxant combos: also know as aspirin/carisoprodol

Coreg vs aspirin/opiate combos: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention. Aspirin/opiate combos: also know as aspirin/carisoprodol/codeine, aspirin/codeine, aspirin/oxycodone

Coreg vs atazanavir: monitor BP, ECG, consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. risk of hypotension, bradycardia, AV block, prolonged PR interval and hepatic metab. inhibited, additive effects

Coreg vs barbiturates: monitor efficacy: combo may decr. carvedilol levels, efficacy and hepatic metab. induced. Barbiturates: also know as butabarbital, methohexital, pentobarbital, phenobarbital, primidone, secobarbital, thiopental

Coreg vs beta blockers, ophthalmic: caution advised, monitor BP, HR, IOP: combo may incr. risk of hypotension, bradycardia, AV block, decr. IOP and additive effects. Beta blockers, ophthalmic: also know as betaxolol ophthalmic, carteolol ophthalmic, dorzolamide/timolol ophthalmic, levobunolol ophthalmic, metipranolol ophthalmic, timolol ophthalmic

Coreg vs bismuth subsalicylate/metronidazole/tetracycline: caution advised w/ high-dose aspirin or salicylates; monitor BP: combo may decr. antihypertensive efficacy and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention

Coreg vs bupropion: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Coreg vs carbamazepine: monitor efficacy: combo may decr. carvedilol levels, efficacy and hepatic metab. induced

Coreg vs CCBs, others: weigh risk/benefit; monitor cardiac fxn closely: combo may incr. risk of hypotension, bradycardia, AV block, conduction defects and additive effects, hepatic metab. of some beta blockers inhibited. CCBs, others: also know as diltiazem, trandolapril/verapamil, verapamil

Coreg vs chlorpromazine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited; additive hypotensive effects

Coreg vs cinacalcet: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Coreg vs cyclosporine: monitor cyclosporine levels: combo may incr. cyclosporine levels, risk of toxicity and mechanism unknown. Cyclosporine: also know as cyclosporine modified, cyclosporine non-modified

Coreg vs dexmedetomidine: monitor BP, ECG: combo may incr. risk of bradycardia, hypotension and additive effects

Coreg vs diazoxide: monitor BP, glucose: combo may incr. or decr. diazoxide hyperglycemic effects; combo w/ IV diazoxide may incr. risk of hypotension and additive/antagonistic effects; additive effects

Coreg vs digoxin: monitor ECG: combo may incr. risk of bradycardia, AV block and additive effects

Coreg vs duloxetine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Coreg vs fluvoxamine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Coreg vs haloperidol: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited. Haloperidol: also know as haloperidol, haloperidol decanoate, haloperidol lactate

Coreg vs hypoglycemics, other: monitor glucose: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism. Hypoglycemics, other: also know as acarbose, metformin, miglitol, nateglinide, repaglinide, sitagliptin/metformin

Coreg vs imatinib: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Coreg vs inhaled anesthetics: caution advised, monitor BP; use for therapeutic advantage to decr BP during surgery: combo may cause prolonged hypotension, decr. cardiac output, other myocardial depressant effects and additive/synergistic effects. Inhaled anesthetics: also know as desflurane, enflurane, isoflurane, sevoflurane

Coreg vs lanreotide: monitor BP, HR; consider lower beta blocker dose: combo may result in bradycardia, altered BP and cardiac conduction abnormalities and additive effects, antagonistic effects

Coreg vs lopinavir/ritonavir: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Coreg vs maraviroc: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. risk of orthostatic hypotension; combo w/ high doses of maraviroc >300 mg bid may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and additive effects; hepatic metab. inhibited

Coreg vs mefloquine: caution advised, monitor ECG: combo may incr. risk of ECG abnormalities, cardiac arrest and mechanism unknown

Coreg vs meperidine/promethazine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited; additive hypotensive effects

Coreg vs metformin/sulfonylurea combos: monitor glucose: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism. Metformin/sulfonylurea combos: also know as glipizide/metformin, glyburide/metformin

Coreg vs octreotide: monitor BP, HR; consider lower beta blocker dose: combo may result in bradycardia, altered BP and cardiac conduction abnormalities and additive effects, antagonistic effects

Coreg vs olanzapine/fluoxetine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited; additive hypotensive effects

Coreg vs perphenazine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited; additive hypotensive effects

Coreg vs phenytoins: monitor efficacy: combo may decr. carvedilol levels, efficacy and hepatic metab. induced. Phenytoins: also know as fosphenytoin, phenytoin

Coreg vs pramlintide: monitor glucose: combo may cause hyperglycemia, prolonged hypoglycemia, mask hypoglycemic sx and adrenergic antagonism

Coreg vs promethazine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited; additive hypotensive effects. Promethazine: also know as promethazine, promethazine rectal

Coreg vs promethazine/codeine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Coreg vs propafenone: caution advised, consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of AV block, other adverse effects and hepatic metab. inhibited; additive effects

Coreg vs propoxyphene: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited. Propoxyphene: also know as propoxyphene HCl, propoxyphene napsylate

Coreg vs quinidine: caution advised, consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. risk of bradycardia, AV block and hepatic metab. inhibited; additive effects. Quinidine: also know as quinidine gluconate, quinidine sulfate

Coreg vs ranolazine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Coreg vs rifampins: monitor efficacy: combo may decr. carvedilol levels, efficacy and hepatic metab. induced. Rifampins: also know as isoniazid/pyrazinamide/rifampin, isoniazid/rifampin, rifampin

Coreg vs ritonavir: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Coreg vs salicylates, non-acetylated: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention. Salicylates, non-acetylated: also know as bismuth subsalicylate, choline magnesium trisalicylate, salsalate

Coreg vs SSRIs 1 2D6 inhibitors: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited. SSRIs 1 2D6 inhibitors: also know as citalopram, escitalopram, fluoxetine, paroxetine, sertraline

Coreg vs terbinafine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Coreg vs thiazolidinediones: monitor glucose: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism. Thiazolidinediones: also know as metformin/pioglitazone, metformin/rosiglitazone, pioglitazone, pioglitazone/glimepiride, rosiglitazone, rosiglitazone/glimepiride

Coreg vs thioridazine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited; additive hypotensive effects

Coreg vs tipranavir: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Coreg vs tizanidine: caution advised, monitor BP: combo may incr. risk of hypotension and additive effects

Coreg vs alfentanil: caution advised: combo may incr. risk of bradycardia, hypotension and additive effects

Coreg vs alpha blockers, non-selective: caution advised: combo may incr. first-dose hypotension, postural hypotension and additive effects. Alpha blockers, non-selective: also know as doxazosin, prazosin, terazosin

Coreg vs antihist/decongest/DM combos: caution advised: combo w/ decongestants may decr. antihypertensive efficacy and antagonistic effects. Antihist/decongest/DM combos: also know as brompheniramine/dextromethorphan/pseudoephedrine, chlorpheniramine/phenylephrine/dextromethorphan

Coreg vs apomorphine: caution advised: combo may incr. risk of orthostatic hypotension, MI, pneumonia, falls, other apomorphine adverse effects and additive effects

Coreg vs beta 2 agonists, all: caution advised: combo may decr. bronchodilating effects, cause bronchospasm; beta 1 cardioselective agents less likely to interact and antagonistic effects. Beta 2 agonists, all: also know as albuterol, albuterol inhaled, albuterol/ipratropium inhaled, arformoterol inhaled, budesonide/formoterol inhaled, fluticasone/salmeterol inhaled, formoterol inhaled, isoproterenol, levalbuterol inhaled, metaproterenol, pirbuterol inhaled, salmeterol inhaled, terbutaline

Coreg vs cetirizine/pseudoephedrine: caution advised: combo may decr. antihypertensive efficacy and antagonistic effects

Coreg vs cholinergic agents: caution advised: combo may alter cardiac conduction and additive effects. Cholinergic agents: also know as bethanechol, cevimeline, pilocarpine

Coreg vs cholinesterase inhibitors: caution advised: combo may alter cardiac conduction, incr. risk of bradycardia, AV block; may incr. risk of bronchospasm and additive effects. Cholinesterase inhibitors: also know as donepezil, edrophonium, galantamine, neostigmine, physostigmine, pyridostigmine, rivastigmine, tacrine

Coreg vs cyclopentolate/phenylephrine ophthalmic: caution advised: combo may rarely cause severe HTN; beta-1 selective agents less likely to interact and antagonistic effects

Coreg vs decongest/opiate combos: caution advised: combo may decr. antihypertensive efficacy and antagonistic effects. Decongest/opiate combos: also know as guaifenesin/hydrocodone/phenylephrine

Coreg vs decongestants: caution advised: combo may decr. antihypertensive efficacy and antagonistic effects. Decongestants: also know as desloratadine/pseudoephedrine, fexofenadine/pseudoephedrine, guaifenesin/phenylephrine, guaifenesin/pseudoephedrine, loratadine/pseudoephedrine, pseudoephedrine

Coreg vs decongestants, intranasal: caution advised: combo may rarely cause severe HTN; beta-1 selective agents less likely to interact and antagonistic effects. Decongestants, intranasal: also know as oxymetazoline nasal, phenylephrine nasal

Coreg vs delavirdine: caution advised: combo may incr. carvedilol levels, risk of adverse effects and hepatic metab. inhibited

Coreg vs diclofenac topical: monitor BP, consider alternatives: combo may decr. antihypertensive efficacy and antagonistic effect; up to 10% systemic absorption of diclofenac topical gel; minimal absorption w/ patch. Diclofenac topical: also know as diclofenac epolamine topical, diclofenac topical

Coreg vs disopyramide: caution advised: combo may incr. risk of cardiac conduction disturbances and additive effects

Coreg vs epinephrine, inhaled: caution advised: combo w/ beta blockers may cause severe HTN then bradycardia, may decr. cardiostim/bronchodilat. effects; beta 1 selective agents less likely to interact and antagonistic effects. Epinephrine, inhaled: also know as epinephrine inhaled, epinephrine, racemic inhaled

Coreg vs ergot alkaloids: caution advised: combo may incr. risk of peripheral vasoconstriction, ischemia and synergistic effects. Ergot alkaloids: also know as dihydroergotamine, dihydroergotamine nasal, methylergonovine

Coreg vs ergotamine/caffeine: caution advised: combo may incr. risk of peripheral vasoconstriction, ischemia and synergistic effects

Coreg vs fibric acid derivatives: caution advised: combo may decr. fibric acid derivative efficacy; beta blockers may exacerbate hypertriglyceridemia and antagonistic effects. Fibric acid derivatives: also know as fenofibrate, fenofibrate micronized, gemfibrozil

Coreg vs flecainide: caution advised: combo may incr. risk of bradycardia, AV block and additive effects

Coreg vs fluphenazine: caution advised: combo may incr. risk of hypotension and additive hypotensive effects. Fluphenazine: also know as fluphenazine, fluphenazine decanoate

Coreg vs iloprost inhaled: caution advised: combo may incr. risk of hypotension and additive/synergistic effects

Coreg vs local anesthetics/epinephrine: caution advised: combo w/ epinephrine may cause severe HTN then bradycardia, may decr. cardiostim/bronchodilatory effects; beta 1 selective agents less likely to interact and antagonistic effects. Local anesthetics/epinephrine: also know as articaine/epinephrine

Coreg vs MAOIs, non-selective: caution advised: combo may incr. risk of hypotension and additive effects. MAOIs, non-selective: also know as isocarboxazid, phenelzine, procarbazine, selegiline transdermal, tranylcypromine

Coreg vs morphine liposomal: caution advised: combo may incr. risk of orthostatic hypotension and additive effects

Coreg vs nitrites/sodium thiosulfate: caution advised: combo w/ nitrites may incr. risk of hypotension and additive effects. Nitrites/sodium thiosulfate: also know as amyl nitrite/sodium nitrite/sodium thiosulfate

Coreg vs omega-3-acid: caution advised: combo may antagonize antihyperlipidemic effect of omega-3-acid and antagonistic effects. Omega-3-acid: also know as omega-3-acid ethyl esters

Coreg vs phenylephrine ophthalmic: caution advised: combo may rarely cause severe HTN; beta-1 selective agents less likely to interact and antagonistic effects

Coreg vs prochlorperazine: caution advised: combo may incr. risk of hypotension and additive hypotensive effects. Prochlorperazine: also know as prochlorperazine edisylate, prochlorperazine maleate, prochlorperazine rectal

Coreg vs reserpine: caution advised: combo may incr. risk of orthostatic hypotension, bradycardia, depression and beta blocker interference w/ reflex tachycardia; additive effects

Coreg vs sitagliptin: caution advised: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism

Coreg vs sotalol: caution advised: combo may incr. risk of hypotension, bradycardia, AV block and additive effects. Sotalol: also know as sotalol, sotalol AF

Coreg vs sufentanil: caution advised: combo w/ beta blockers may incr. risk of bradycardia, hypotension and additive effects

Coreg vs sulfonylureas: caution advised: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism. Sulfonylureas: also know as chlorpropamide, glimepiride, glipizide, glyburide, glyburide micronized, tolazamide, tolbutamide

Coreg vs sympathomimetics, direct: caution advised: combo may cause severe HTN then bradycardia, may decr. cardiostim/bronchodilat. effects; beta 1 selective agents less likely to interact and antagonistic effects. Sympathomimetics, direct: also know as dobutamine, epinephrine, isoproterenol, norepinephrine, phenylephrine

Coreg vs sympathomimetics, indirect/mixed: caution advised: combo may decr. vasopressor, cardiostimulating, bronchodilating effects; beta 1 selective agents less likely to interact and antagonistic effects. Sympathomimetics, indirect/mixed: also know as acetaminophen/dichloralphenazone/isometheptene, dopamine, ephedrine

Coreg vs tadalafil: caution advised: combo may incr. risk of hypotension and additive effects

Coreg vs trifluoperazine: caution advised: combo may incr. risk of hypotension and additive hypotensive effects

Coreg: Adverse Reactions

CHF

heart block

bradycardia, severe

angina exacerbation

asthma

bronchospasm

anaphylactoid rxns (rare)

hypersensitivity rxn

Stevens-Johnson syndrome (rare)

toxic epidermal necrolysis (rare)

erythema multiforme (rare)

exfoliative dermatitis (rare)

photosensitivity

leukopenia

thrombocytopenia

anemia

anemia, aplastic (rare)

pneumonitis, interstitial (rare)

dizziness

fatigue

diarrhea

hyperglycemia

weight gain

hypotension

bradycardia

dyspnea

nausea

headache

asthenia

vomiting

arthralgia

elevated BUN

abnormal vision

edema

hypercholesterolemia

rales

syncope

angina

anemia

pulmonary edema

elevated liver transaminases

Did you know?

Yes, Coreg today sold under many names; here is only few:

→ Carvedilol
→ Dilatrend
→ Eucardic

Buy any from these brand names you receice medicine contain same active ingredient as contain original Coreg

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