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Manufacturer of Lopressor

Novartis Pharmaceuticals

Also know under brand names: Lopressor, Toprol-XL

Active ingredient / generic name: metoprolol

Approximate US Retail Price for Lopressor

50 mg (60 ea): $90.99
100 mg (60 ea): $123.93

Short leaflet

Lopressor is a selective beta₁ receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension. It is marketed under the brand name Lopressor or Lopresor, respectively, by Novartis, and Toprol-XL (in the USA); Selokeen (in Nederlands); as Minax by Alphapharm (in Australia), Metrol by Arrow Pharmaceuticals (in Australia), as Betaloc by AstraZeneca, as Neobloc by Unipharm (in Israel) and as Corvitol by Berlin-Chemie AG. A number of generic products is available, too. The active substance Lopressor is employed either as Lopressor succinate or Lopressor tartrate (whereas 100 mg Lopressor tartrate corresponds to 95 mg Lopressor succinate), as conventional release- or prolonged-release formulation.

Lopressor is very low melting. Its melting point is around 45 degrees Celsius (as determined by Differential scanning calorimetry). For this reason Lopressor is always manufactured in salt form, as drugs with melting points below 100 degrees Celsius are difficult to work with in a manufacturing environment. The free base exists as a waxy white solid, where the tartrate salt is finer crystalline material.

Due to its selectivity in blocking the beta₁ receptors in the heart, Lopressor is also prescribed for off-label use in performance anxiety, social anxiety disorder, and other anxiety disorders.

Transient effects include dizziness, lightheadedness, drowsiness, tiredness, diarrhea, unusual dreams, ataxia, trouble sleeping, and vision problems. It may also reduce blood flow to the hands and feet, causing them to feel numb and cold; smoking may worsen this effect.

Serious side effects that are not to be tolerated for any length of time include symptoms of a very slow heartbeat (less than 50 bpm) (e.g. persistent dizziness, fainting, unusual fatigue), bluish discoloration of the fingers and toes, numbness/tingling/swelling of the hands or feet, sexual dysfunction, erectile dysfunction (impotence), hair loss, mental/mood changes, trouble breathing, cough, and increased thirst. Other highly unlikely symptoms include easy bruising or bleeding, persistent sore throat or fever, yellowing skin or eyes, stomach pain, dark urine, and persistent nausea. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness. Taking it with alcohol might cause mild body rashes and therefore is not recommended.

Lopressor: Patient Education

Do not stop taking metoprolol without first talking to your doctor. Stopping suddenly may make your condition worse.

If you need to have any type of surgery, you may need to temporarily stop using metoprolol. Be sure the surgeon knows ahead of time that you are using metoprolol.

Metoprolol can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol, which could increase drowsiness and dizziness while you are taking metoprolol.

Metoprolol is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely if you are being treated for hypertension.

Hypertension often has no symptoms, so you may not even feel that you have high blood pressure. Continue using this medicine as directed, even if you feel well. You may need to use blood pressure medication for the rest of your life.

Metoprolol is in a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).

Metoprolol is used to treat angina (chest pain) and hypertension (high blood pressure). It is also used to treat or prevent heart attack.

Metoprolol may also be used for purposes other than those listed in this medication guide.

Do not use this medication if you are allergic to metoprolol, or if you have:

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Metoprolol can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Take metoprolol exactly as it was prescribed for you. Do not take the medication in larger amounts or for longer than recommended by your doctor.

Take this medication with a full glass of water.

Take metoprolol at the same time every day.

Metoprolol should be taken with food or just after a meal.

A Toprol XL tablet can be divided in half if your doctor has told you to do so. The half tablet should be swallowed whole, without chewing or crushing. Chewing or crushing the pill could cause too much of the drug to be released at one time.

Do not skip doses or stop taking metoprolol without first talking to your doctor. Stopping suddenly may make your condition worse.

To be sure this medication is helping your condition, your blood pressure will need to be checked on a regular basis. It is important that you not miss any scheduled visits to your doctor.

If you need to have any type of surgery, tell the surgeon that you are using metoprolol. You may need to briefly stop using metoprolol before having surgery.

Metoprolol is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely if you are being treated for hypertension.

Hypertension often has no symptoms, so you may not even feel that you have high blood pressure. Continue using this medicine as directed, even if you feel well. You may need to use blood pressure medication for the rest of your life.

Store metoprolol at room temperature away from moisture and heat.

Take the missed dose as soon as you remember. If your next dose is less than 4 hours away, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a metoprolol overdose may include uneven heartbeats, shortness of breath, bluish-colored fingernails, dizziness, weakness, fainting, or seizure (convulsions).

Metoprolol can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol, which could increase drowsiness and dizziness while you are taking metoprolol.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

Before taking metoprolol, tell your doctor if you are using:

There may be other drugs not listed that can affect metoprolol. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Your pharmacist has additional information about metoprolol written for health professionals that you may read.

Lopressor: Dosing

HTN:

50-200 mg PO bid: Start: 50 mg PO bid, may incr. dose qwk; Max: 450 mg/day; Info: give w/ meals

angina:

50-200 mg PO bid: Start: 50 mg PO bid, may incr. dose qwk; Max: 400 mg/day; Info: give w/ meals; taper dose gradually over 1-2wk to D/C

MI, acute:

100 mg PO bid: Start: 5 mg IV q2min x3; after 15min, give 50 mg PO q6h x48h, then incr. to target dose; Info: may give 25 mg PO q6h if unable to tolerate full IV dose

cardiovascular event prevention, post-MI:

100 mg PO bid: Info: start ASAP after pt stable

renal dosing:

no adjustment: HD: give supplement

Lopressor: Drug Interactions

Lopressor vs central alpha 2 agonists: use alternative or monitor BP, D/C beta blocker first: combo may decr. antihypertensive response to alpha 2 agonist, incr. risk of severe rebound HTN on alpha 2 agonist withdrawal and antagonistic effects, unopposed alpha adrenergic stimulation. Central alpha 2 agonists: also know as clonidine, clonidine transdermal, guanabenz, guanfacine, methyldopa

Lopressor vs cimetidine: use alternative or non-hepatically metabolized beta blocker e.g. atenolol, nadolol: combo may incr. risk of bradycardia, hypotension and hepatic metab. inhibited

Lopressor vs cocaine topical: avoid combo: combo may result in unopposed alpha-adrenergic stimulation w/ incr. risk of HTN, severe vasoconstriction, arrhythmias and additive effects

Lopressor vs COX 2 inhibitors: monitor BP, use alternative: combo may cause sodium/water retention, decr. antihypertensive efficacy and antagonistic effects. COX 2 inhibitors: also know as celecoxib

Lopressor vs fenoldopam: avoid combo: combo may incr. risk of hypotension and beta blocker interference w/ reflex tachycardia; additive effects

Lopressor vs hydrocodone/ibuprofen: monitor BP, consider alternatives: combo may decr. antihypertensive efficacy and antagonistic effect due to NSAID-induced inhibition of renal prostaglandins, sodium and fluid retention

Lopressor vs ibuprofen/oxycodone: monitor BP, consider alternatives: combo may decr. antihypertensive efficacy and antagonistic effect due to NSAID-induced inhibition of renal prostaglandins, sodium and fluid retention

Lopressor vs insulins: use alternative: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism. Insulins: also know as insulin aspart, insulin aspart protamine/insulin aspart, insulin detemir, insulin glargine, insulin glulisine, insulin inhaled, insulin lispro, insulin lispro protamine/insulin lispro, insulin NPH, insulin NPH/regular, insulin regular

Lopressor vs lansoprazole/naproxen: monitor BP, consider alternatives: combo w/ NSAIDs may cause sodium/water retention, decr. antihypertensive efficacy and antagonistic effects

Lopressor vs NSAIDs: monitor BP, consider alternatives: combo may decr. antihypertensive efficacy and antagonistic effect due to NSAID-induced inhibition of renal prostaglandins, sodium and fluid retention. NSAIDs: also know as diclofenac potassium, diclofenac sodium, diclofenac/misoprostol, diflunisal, etodolac, fenoprofen, flurbiprofen, ibuprofen, ibuprofen lysine, indomethacin, ketoprofen, ketorolac, meclofenamate, mefenamic acid, meloxicam, nabumetone, naproxen, naproxen sodium, oxaprozin, piroxicam, sulindac, tolmetin

Lopressor vs acetaminophen/propoxyphene: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, other adverse effects and hepatic metab. inhibited. Acetaminophen/propoxyphene: also know as acetaminophen/propoxyphene HCl, acetaminophen/propoxyphene napsylate

Lopressor vs alpha 2 agonists, ophthalmic: caution advised, monitor BP, HR: combo may incr. risk of hypotension, bradycardia, AV block and additive effects. Alpha 2 agonists, ophthalmic: also know as apraclonidine ophthalmic, brimonidine ophthalmic

Lopressor vs alpha 2 agonists/beta blockers, ophthalmic: caution advised, monitor BP, HR, IOP: combo may incr. risk of hypotension, bradycardia, AV block, decr. IOP and additive effects. Alpha 2 agonists/beta blockers, ophthalmic: also know as brimonidine/timolol ophthalmic

Lopressor vs amiodarone: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, sinus arrest, AV block, other adverse effects and hepatic metab. inhibited; additive effects

Lopressor vs amitriptyline/perphenazine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited; additive hypotensive effects

Lopressor vs antihist/decongestant combos: caution advised, monitor BP: combo w/ decongestants may decr. antihypertensive efficacy and antagonistic effects. Antihist/decongestant combos: also know as acrivastine/pseudoephedrine, brompheniramine/phenylephrine, chlorpheniramine/phenylephrine, chlorpheniramine/pseudoephedrine, pseudoephedrine/triprolidine

Lopressor vs aspirin/butalbital/caffeine: caution advised, monitor BP: combo w/ high dose aspirin or salicylates may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention

Lopressor vs aspirin/butalbital/caffeine/codeine: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention

Lopressor vs aspirin/caffeine/dihydrocodeine: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive efficacy and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention

Lopressor vs aspirin/caffeine/orphenadrine: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention

Lopressor vs aspirin/dipyridamole: caution advised, monitor BP: combo w/ high dose aspirin or salicylates may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention

Lopressor vs aspirin/muscle relaxant combos: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention. Aspirin/muscle relaxant combos: also know as aspirin/carisoprodol

Lopressor vs aspirin/opiate combos: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention. Aspirin/opiate combos: also know as aspirin/carisoprodol/codeine, aspirin/codeine, aspirin/oxycodone

Lopressor vs atazanavir: monitor BP, ECG, consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. risk of hypotension, bradycardia, AV block, prolonged PR interval and hepatic metab. inhibited, additive effects

Lopressor vs beta blockers, ophthalmic: caution advised, monitor BP, HR, IOP: combo may incr. risk of hypotension, bradycardia, AV block, decr. IOP and additive effects. Beta blockers, ophthalmic: also know as betaxolol ophthalmic, carteolol ophthalmic, dorzolamide/timolol ophthalmic, levobunolol ophthalmic, metipranolol ophthalmic, timolol ophthalmic

Lopressor vs bismuth subsalicylate/metronidazole/tetracycline: caution advised w/ high-dose aspirin or salicylates; monitor BP: combo may decr. antihypertensive efficacy and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention

Lopressor vs bupropion: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Lopressor vs CCBs, others: weigh risk/benefit; monitor cardiac fxn closely: combo may incr. risk of hypotension, bradycardia, AV block, conduction defects and additive effects, hepatic metab. of some beta blockers inhibited. CCBs, others: also know as diltiazem, trandolapril/verapamil, verapamil

Lopressor vs chlorpromazine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited; additive hypotensive effects

Lopressor vs cinacalcet: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Lopressor vs dexmedetomidine: monitor BP, ECG: combo may incr. risk of bradycardia, hypotension and additive effects

Lopressor vs diazoxide: monitor BP, glucose: combo may incr. or decr. diazoxide hyperglycemic effects; combo w/ IV diazoxide may incr. risk of hypotension and additive/antagonistic effects; additive effects

Lopressor vs digoxin: monitor ECG: combo may incr. risk of bradycardia, AV block and additive effects

Lopressor vs duloxetine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Lopressor vs fluvoxamine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Lopressor vs hydralazine: monitor BP, consider dose adjustments for both drugs: combo may incr. beta blocker levels, hypotensive efficacy, adverse effects and mechanism unknown, possibly due to altered hepatic blood flow and decr. hepatic metabolism

Lopressor vs hydralazine/hydrochlorothiazide: monitor BP, consider dose adjustments for both drugs: combo w/ hydralazine may incr. beta blocker levels, hypotensive efficacy, adverse effects and mechanism unknown, possibly due to altered hepatic blood flow and decr. hepatic metabolism

Lopressor vs hydralazine/isosorbide dinitrate: monitor BP, consider dose adjustments for both drugs: combo w/ hydralazine may incr. beta blocker levels, hypotensive efficacy, adverse effects and mechanism unknown, possibly due to altered hepatic blood flow and decr. hepatic metabolism

Lopressor vs hypoglycemics, other: monitor glucose: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism. Hypoglycemics, other: also know as acarbose, metformin, miglitol, nateglinide, repaglinide, sitagliptin/metformin

Lopressor vs imatinib: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Lopressor vs inhaled anesthetics: caution advised, monitor BP; use for therapeutic advantage to decr BP during surgery: combo may cause prolonged hypotension, decr. cardiac output, other myocardial depressant effects and additive/synergistic effects. Inhaled anesthetics: also know as desflurane, enflurane, isoflurane, sevoflurane

Lopressor vs lanreotide: monitor BP, HR; consider lower beta blocker dose: combo may result in bradycardia, altered BP and cardiac conduction abnormalities and additive effects, antagonistic effects

Lopressor vs lopinavir/ritonavir: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Lopressor vs maraviroc: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. risk of orthostatic hypotension; combo w/ high doses of maraviroc >300 mg bid may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and additive effects; hepatic metab. inhibited

Lopressor vs mefloquine: caution advised, monitor ECG: combo may incr. risk of ECG abnormalities, cardiac arrest and mechanism unknown

Lopressor vs meperidine/promethazine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited; additive hypotensive effects

Lopressor vs metformin/sulfonylurea combos: monitor glucose: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism. Metformin/sulfonylurea combos: also know as glipizide/metformin, glyburide/metformin

Lopressor vs octreotide: monitor BP, HR; consider lower beta blocker dose: combo may result in bradycardia, altered BP and cardiac conduction abnormalities and additive effects, antagonistic effects

Lopressor vs olanzapine/fluoxetine: monitor BP, HR: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, excessive beta blockade and hepatic metab. inhibited; additive hypotensive effects

Lopressor vs pramlintide: monitor glucose: combo may cause hyperglycemia, prolonged hypoglycemia, mask hypoglycemic sx and adrenergic antagonism

Lopressor vs promethazine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited; additive hypotensive effects. Promethazine: also know as promethazine, promethazine rectal

Lopressor vs promethazine/codeine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited; additive hypotensive effects

Lopressor vs propafenone: caution advised, consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of AV block, other adverse effects and hepatic metab. inhibited; additive effects

Lopressor vs propoxyphene: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited. Propoxyphene: also know as propoxyphene HCl, propoxyphene napsylate

Lopressor vs quinidine: caution advised, consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. risk of bradycardia, AV block and hepatic metab. inhibited; additive effects. Quinidine: also know as quinidine gluconate, quinidine sulfate

Lopressor vs ranolazine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Lopressor vs ritonavir: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Lopressor vs salicylates, non-acetylated: caution advised, monitor BP, especially w/ high dose aspirin or salicylates: combo may decr. antihypertensive effects and antagonistic effects; salicylate-induced inhibition of renal prostaglandins, sodium and fluid retention. Salicylates, non-acetylated: also know as bismuth subsalicylate, choline magnesium trisalicylate, salsalate

Lopressor vs SSRIs 1 2D6 inhibitors: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited. SSRIs 1 2D6 inhibitors: also know as citalopram, escitalopram, fluoxetine, paroxetine, sertraline

Lopressor vs telithromycin: caution advised, especially in heart failure: combo may incr. metoprolol levels, risk of hypotension, bradycardia, AV block, other adverse effects and mechanism unknown, hepatic metab. possibly inhibited

Lopressor vs terbinafine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Lopressor vs thiazolidinediones: monitor glucose: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism. Thiazolidinediones: also know as metformin/pioglitazone, metformin/rosiglitazone, pioglitazone, pioglitazone/glimepiride, rosiglitazone, rosiglitazone/glimepiride

Lopressor vs thioridazine: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited; additive hypotensive effects

Lopressor vs tipranavir: monitor BP, HR; consider lower beta blocker dose or non-hepatically metabolized beta blocker: combo may incr. beta blocker levels, risk of hypotension, bradycardia, AV block, other adverse effects and hepatic metab. inhibited

Lopressor vs tizanidine: caution advised, monitor BP: combo may incr. risk of hypotension and additive effects

Lopressor vs alfentanil: caution advised: combo may incr. risk of bradycardia, hypotension and additive effects

Lopressor vs alpha blockers, non-selective: caution advised: combo may incr. first-dose hypotension, postural hypotension and additive effects. Alpha blockers, non-selective: also know as doxazosin, prazosin, terazosin

Lopressor vs antihist/decongest/DM combos: caution advised: combo w/ decongestants may decr. antihypertensive efficacy and antagonistic effects. Antihist/decongest/DM combos: also know as brompheniramine/dextromethorphan/pseudoephedrine, chlorpheniramine/phenylephrine/dextromethorphan

Lopressor vs apomorphine: caution advised: combo may incr. risk of orthostatic hypotension, MI, pneumonia, falls, other apomorphine adverse effects and additive effects

Lopressor vs beta 2 agonists, all: caution advised: combo may decr. bronchodilating effects, cause bronchospasm; beta 1 cardioselective agents less likely to interact and antagonistic effects. Beta 2 agonists, all: also know as albuterol, albuterol inhaled, albuterol/ipratropium inhaled, arformoterol inhaled, budesonide/formoterol inhaled, fluticasone/salmeterol inhaled, formoterol inhaled, isoproterenol, levalbuterol inhaled, metaproterenol, pirbuterol inhaled, salmeterol inhaled, terbutaline

Lopressor vs cetirizine/pseudoephedrine: caution advised: combo may decr. antihypertensive efficacy and antagonistic effects

Lopressor vs cholinergic agents: caution advised: combo may alter cardiac conduction and additive effects. Cholinergic agents: also know as bethanechol, cevimeline, pilocarpine

Lopressor vs cholinesterase inhibitors: caution advised: combo may alter cardiac conduction, incr. risk of bradycardia, AV block; may incr. risk of bronchospasm and additive effects. Cholinesterase inhibitors: also know as donepezil, edrophonium, galantamine, neostigmine, physostigmine, pyridostigmine, rivastigmine, tacrine

Lopressor vs cyclopentolate/phenylephrine ophthalmic: caution advised: combo may rarely cause severe HTN; beta-1 selective agents less likely to interact and antagonistic effects

Lopressor vs decongest/opiate combos: caution advised: combo may decr. antihypertensive efficacy and antagonistic effects. Decongest/opiate combos: also know as guaifenesin/hydrocodone/phenylephrine

Lopressor vs decongestants: caution advised: combo may decr. antihypertensive efficacy and antagonistic effects. Decongestants: also know as desloratadine/pseudoephedrine, fexofenadine/pseudoephedrine, guaifenesin/phenylephrine, guaifenesin/pseudoephedrine, loratadine/pseudoephedrine, pseudoephedrine

Lopressor vs decongestants, intranasal: caution advised: combo may rarely cause severe HTN; beta-1 selective agents less likely to interact and antagonistic effects. Decongestants, intranasal: also know as oxymetazoline nasal, phenylephrine nasal

Lopressor vs diclofenac topical: monitor BP, consider alternatives: combo may decr. antihypertensive efficacy and antagonistic effect; up to 10% systemic absorption of diclofenac topical gel; minimal absorption w/ patch. Diclofenac topical: also know as diclofenac epolamine topical, diclofenac topical

Lopressor vs disopyramide: caution advised: combo may incr. risk of cardiac conduction disturbances and additive effects

Lopressor vs epinephrine, inhaled: caution advised: combo w/ beta blockers may cause severe HTN then bradycardia, may decr. cardiostim/bronchodilat. effects; beta 1 selective agents less likely to interact and antagonistic effects. Epinephrine, inhaled: also know as epinephrine inhaled, epinephrine, racemic inhaled

Lopressor vs ergot alkaloids: caution advised: combo may incr. risk of peripheral vasoconstriction, ischemia and synergistic effects. Ergot alkaloids: also know as dihydroergotamine, dihydroergotamine nasal, methylergonovine

Lopressor vs ergotamine/caffeine: caution advised: combo may incr. risk of peripheral vasoconstriction, ischemia and synergistic effects

Lopressor vs fibric acid derivatives: caution advised: combo may decr. fibric acid derivative efficacy; beta blockers may exacerbate hypertriglyceridemia and antagonistic effects. Fibric acid derivatives: also know as fenofibrate, fenofibrate micronized, gemfibrozil

Lopressor vs flecainide: caution advised: combo may incr. risk of bradycardia, AV block and additive effects

Lopressor vs fluphenazine: caution advised: combo may incr. risk of hypotension and additive effects. Fluphenazine: also know as fluphenazine, fluphenazine decanoate

Lopressor vs gefitinib: caution advised: combo may incr. metoprolol levels, risk of adverse effects and hepatic metab. inhibited

Lopressor vs iloprost inhaled: caution advised: combo may incr. risk of hypotension and additive/synergistic effects

Lopressor vs local anesthetics/epinephrine: caution advised: combo w/ epinephrine may cause severe HTN then bradycardia, may decr. cardiostim/bronchodilatory effects; beta 1 selective agents less likely to interact and antagonistic effects. Local anesthetics/epinephrine: also know as articaine/epinephrine

Lopressor vs MAOIs, non-selective: caution advised: combo may incr. risk of hypotension and additive effects. MAOIs, non-selective: also know as isocarboxazid, phenelzine, procarbazine, selegiline transdermal, tranylcypromine

Lopressor vs morphine liposomal: caution advised: combo may incr. risk of orthostatic hypotension and additive effects

Lopressor vs nitrites/sodium thiosulfate: caution advised: combo w/ nitrites may incr. risk of hypotension and additive effects. Nitrites/sodium thiosulfate: also know as amyl nitrite/sodium nitrite/sodium thiosulfate

Lopressor vs omega-3-acid: caution advised: combo may antagonize antihyperlipidemic effect of omega-3-acid and antagonistic effects. Omega-3-acid: also know as omega-3-acid ethyl esters

Lopressor vs phenylephrine ophthalmic: caution advised: combo may rarely cause severe HTN; beta-1 selective agents less likely to interact and antagonistic effects

Lopressor vs prochlorperazine: caution advised: combo may incr. risk of hypotension and additive effects. Prochlorperazine: also know as prochlorperazine edisylate, prochlorperazine maleate, prochlorperazine rectal

Lopressor vs reserpine: caution advised: combo may incr. risk of orthostatic hypotension, bradycardia, depression and beta blocker interference w/ reflex tachycardia; additive effects

Lopressor vs sitagliptin: caution advised: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism

Lopressor vs sotalol: caution advised: combo may incr. risk of hypotension, bradycardia, AV block and additive effects. Sotalol: also know as sotalol, sotalol AF

Lopressor vs sufentanil: caution advised: combo w/ beta blockers may incr. risk of bradycardia, hypotension and additive effects

Lopressor vs sulfonylureas: caution advised: combo may alter glucose metab., prolong hypoglycemia, mask hypoglycemic sx and adrenergic antagonism. Sulfonylureas: also know as chlorpropamide, glimepiride, glipizide, glyburide, glyburide micronized, tolazamide, tolbutamide

Lopressor vs sympathomimetics, direct: caution advised: combo may cause severe HTN then bradycardia, may decr. cardiostim/bronchodilat. effects; beta 1 selective agents less likely to interact and antagonistic effects. Sympathomimetics, direct: also know as dobutamine, epinephrine, isoproterenol, norepinephrine, phenylephrine

Lopressor vs sympathomimetics, indirect/mixed: caution advised: combo may decr. vasopressor, cardiostimulating, bronchodilating effects; beta 1 selective agents less likely to interact and antagonistic effects. Sympathomimetics, indirect/mixed: also know as acetaminophen/dichloralphenazone/isometheptene, dopamine, ephedrine

Lopressor vs tadalafil: caution advised: combo may incr. risk of hypotension and additive effects

Lopressor vs trifluoperazine: caution advised: combo may incr. risk of hypotension and additive effects

Lopressor: Adverse Reactions

CHF

heart block

cardiogenic shock (MI pts)

bradycardia, severe

Raynaud's phenomenon

gangrene (rare)

bronchospasm

hepatitis (rare)

hypersensitivity rxn

photosensitivity (rare)

fatigue

dizziness

diarrhea

pruritus

rash

depression

dyspnea

bradycardia

Did you know?

Yes, Lopressor today sold under many names; here is only few:

→ Metoprolol
→ Toprol-XL
→ Lopresor
→ Selokeen
→ Minax
→ Metrol
→ Betaloc
→ Neobloc
→ Corvitol

Buy any from these brand names you receice medicine contain same active ingredient as contain original Lopressor

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